Targeting ENPP1 for cancer immunotherapy: Killing two birds with one stone

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成果类型：

期刊论文

作者：

Huang, Ruilei;Ning, Qian;Zhao, Jihui;Zhao, Xuhong;Zeng, Luting;...

通讯作者：

Tang, SS

作者机构：

[Zhao, Jihui; Tang, SS; Tang, Shengsong; Zeng, Luting; Zhao, Xuhong; Ning, Qian; Huang, Ruilei; Yi, Yi] Hunan Univ Med, Sch Pharmaceut Sci, Hunan Prov Key Lab Antibody Based Drug & Intellig, Huaihua 418000, Peoples R China.

[Tang, Shengsong; Ning, Qian] Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Peoples R China.

[Tang, Shengsong] Univ South China, Hunan Prov Key Lab Tumor Microenvironm Respons Dru, Hengyang 421001, Peoples R China.

[Tang, Shengsong] Univ South China, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.

通讯机构：

[Tang, SS ] H

Hunan Univ Med, Sch Pharmaceut Sci, Hunan Prov Key Lab Antibody Based Drug & Intellig, Huaihua 418000, Peoples R China.

语种：

英文

关键词：

Adenosine;ENPP1;ENPP1 inhibitors;Immunotherapy;cGAMP;cGAS-STING signaling pathway

期刊：

Biochemical Pharmacology

ISSN：

0006-2952

年：

2024

卷：

220

页码：

116006

DOI：

10.1016/j.bcp.2023.116006

基金类别：

Hunan Provincial Science and Technology Plan Key Projects of China [2017SK2183]; Scientific Research Project of Hunan Provincial Health Commission [202113022028]; Scientific Research Fund of Hunan Provincial Education Department [21C1379, 22B1039]; Hunan Provincial Natural Science Foundation of China [2023JJ50444, 2023JJ50076]

机构署名：

本校为其他机构

院系归属：

生物科学技术学院

摘要：

Cancer immunotherapy, particularly with immune checkpoint inhibitors, has revolutionized the paradigm of cancer treatment. Nevertheless, the efficacy of cancer immunotherapy remains limited in most clinical settings due to the lack of a preexisting antitumor T-cell response in tumors. Therefore, the clinical outcomes of cancer immunotherapy must be improved crucially. With increased awareness of the importance of the innate immune response in the recruitment of T cells, as well as the onset and maintenance of the T cell response, great interest has been shown in activating the cGAS-STING signa...

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Targeting ENPP1 for cancer immunotherapy: Killing two birds with one stone

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