Alteration of Mevalonate Pathway in Rat Splenic Lymphocytes: Possible Role in Cytokines Secretion Regulated by L-Theanine

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期刊论文

作者：

Li, Chengjian;Yan, Qiongxian*;Tang, Shaoxun;Xiao, Wenjun*;Tan, Zhiliang

通讯作者：

Yan, Qiongxian;Xiao, Wenjun

作者机构：

[Tang, Shaoxun; Yan, Qiongxian; Tan, Zhiliang; Li, Chengjian] Chinese Acad Sci, Key Lab Agroecol Proc Subtrop Reg,Inst Subtrop Ag, Natl Engn Lab Pollut Control & Waste Utilizat Liv, South Cent Expt Stn Anim Nutr & Feed Sci,Minist A, Changsha 410125, Hunan, Peoples R China.

[Li, Chengjian] Xiangnan Univ, Coll Pharmaceut Sci, Chenzhou 423000, Peoples R China.

[Li, Chengjian] Yongzhou Vocat Tech Coll, Dept Pharm, Yongzhou 425100, Hunan, Peoples R China.

[Yan, Qiongxian; Xiao, Wenjun; Xiao, WJ] Hunan Agr Univ, Natl Res Ctr Engn Technol Utilizat Bot Funct Ingr, Prov Coinnovat Ctr Utilizat Bot Funct Ingredients, Changsha 410128, Hunan, Peoples R China.

[Tang, Shaoxun; Tan, Zhiliang] CICAPS, Hunan Coinnovat Ctr Anim Prod Safety, Changsha 410128, Hunan, Peoples R China.

通讯机构：

[Yan, Qiongxian] C

[Yan, QX; Xiao, WJ] H

Chinese Acad Sci, Key Lab Agroecol Proc Subtrop Reg,Inst Subtrop Ag, Natl Engn Lab Pollut Control & Waste Utilizat Liv, South Cent Expt Stn Anim Nutr & Feed Sci,Minist A, Changsha 410125, Hunan, Peoples R China.

Hunan Agr Univ, Natl Res Ctr Engn Technol Utilizat Bot Funct Ingr, Prov Coinnovat Ctr Utilizat Bot Funct Ingredients, Changsha 410128, Hunan, Peoples R China.

语种：

英文

期刊：

BioMed Research International

ISSN：

2314-6133

年：

2018

卷：

2018

期：

页码：

1-8

DOI：

10.1155/2018/1497097

基金类别：

T he work was done in the Institute of Subtropical Agriculture Chinese Academy of Sciences and was supported by the Hunan Provincial Creation Development Project (2013TF3006), the National Natural Science Foundation of China (Grants nos. 31320103917 and 31172234), and the Youth Innovation Team Project of ISA, CAS (Grant no. 2017QNCXTD ZCS).

机构署名：

本校为通讯机构

院系归属：

园艺园林学院

摘要：

L-Theanine is a nonprotein amino acid in tea, and its immunomodulatory function has been confirmed. This study aimed to investigate the effect of L-theanine addition on cytokines secretion in rat splenic lymphocytes and explore its potential immunomodulatory effects on the mevalonate biosynthetic pathway. Our results showed that L-theanine treatment did not influence the proliferation and division indexes of the splenic lymphocytes subsets. Interestingly, L-theanine treatment had regulated the contents of IFN-γ, IL-2, IL-4, IL-10, IL-12, and T...

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Alteration of Mevalonate Pathway in Rat Splenic Lymphocytes: Possible Role in Cytokines Secretion Regulated by L-Theanine

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