l-Theanine, an active ingredient in the tea plant (Camellia sinensis) associated with calming, is widely used as a functional ingredient and dietary supplement. In this study, a heat stress mouse model was used to evaluate the anti-heat stress effect of l-theanine and its possible mechanism of action. Mice subjected to heat stress (40 °C) that were administered l-theanine at various doses (100, 200, and 400 mg kg-1 d-1) had reduced oxidative stress and inflammatory factors when l-theanine was administered both long-term and as a preventative t...