期刊论文

Liu Xia

英文

中国化学

1001-604X

2011

29

1

165-170

10.1002/cjoc.201190046

National High Technology Research and Development Program of China (863 Program)National High Technology Research and Development Program of China [2008AA100801-B1]; Hunan Provincial Education DepartmentHunan Provincial Education Department [10B050]; Science Foundation for Introduction Scholars of Hunan Agricultural University of China [08YJ07]

本校为第一且通讯机构

A surface plasmon resonance (SPR) biosensor based on wavelength modulation technology was developed and validated for the kinetic analysis of the interactions between two nonsteroidal anti-inflammatory drugs (NSAIDs) and cyclooxygenase-2 (COX-2). After the effect of different concentration COX-2 on the binding capacity of the SPR biosensor surface was studied, the COX-2 was immobilized covalently onto the biosensor surface using a standard amine coupling method. The affinity constants for indomethacin, ketoprofen binding to COX-2 are 7.5×103 L...

一个表面电浆子回声(SPR ) 生物传感器为在二 nonsteroidal 之间的相互作用的运动分析基于波长调整技术被发展并且验证反煽动性的药(NSAID ) 和 cyclooxygenase-2 (COX-2 ) 。在 SPR 生物传感器表面的有约束力的能力上的不同集中 COX-2 的效果被学习以后， COX-2 用联合方法的标准胺 covalently 被使不能调动到生物传感器表面上。为消炎痛的亲密关系常数，对 COX-2 有约束力的 ketoprofen 是 7.5lithophile 元素当高领域力量元素稍微弄空时，显然被集中， Ta 和 Nb 的出现清楚的否定异例，和 Ti 的弱缺乏。REE 是很吗？？