Potential Mechanisms Connecting Purine Metabolism and Cancer Therapy

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成果类型：

期刊论文

作者：

Yin, Jie;Ren, Wenkai*;Huang, Xingguo;Deng, Jinping;Li, Tiejun*;...

通讯作者：

Ren, Wenkai;Yin, Yulong;Li, Tiejun

作者机构：

[Yin, Jie; Ren, Wenkai; Ren, WK; Yin, YL; Deng, Jinping; Yin, Yulong] South China Agr Univ, Inst Subtrop Anim Nutr & Feed, Coll Anim Sci, Guangdong Prov Key Lab Anim Nutr Control, Guangzhou, Guangdong, Peoples R China.

[Yin, Jie; Li, Tiejun; Yin, YL; Yin, Yulong] Chinese Acad Sci, Key Lab Agroecol Proc Subtrop Reg,Inst Subtrop Ag, Sci Observing & Expt Stn Anim Nutr & Feed Sci Sou, Minist Agr,Hunan Prov Engn Res Ctr Hlth Livestock, Changsha, Hunan, Peoples R China.

[Yin, Jie; Huang, Xingguo] Univ Chinese Acad Sci, Beijing, Peoples R China.

[Huang, Xingguo] Hunan Agr Univ, Dept Anim Sci, Changsha, Hunan, Peoples R China.

通讯机构：

[Ren, WK; Yin, YL] S

[Li, TJ; Yin, YL] C

South China Agr Univ, Inst Subtrop Anim Nutr & Feed, Coll Anim Sci, Guangdong Prov Key Lab Anim Nutr Control, Guangzhou, Guangdong, Peoples R China.

Chinese Acad Sci, Key Lab Agroecol Proc Subtrop Reg,Inst Subtrop Ag, Sci Observing & Expt Stn Anim Nutr & Feed Sci Sou, Minist Agr,Hunan Prov Engn Res Ctr Hlth Livestock, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

*cancers;*mammalian target of rapamycin;*metabolism;*purine;*purinosome

期刊：

FRONTIERS IN IMMUNOLOGY

ISSN：

1664-3224

年：

2018

卷：

页码：

1697

DOI：

10.3389/fimmu.2018.01697

基金类别：

National Basic Research Program of China (973)National Basic Research Program of China [2013CB127301]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31472106]; Hunan Key Research Program [2017NK2320]; China Agriculture Research System [CARS-35]

机构署名：

本校为其他机构

院系归属：

动物科学技术学院

摘要：

Unrestricted cell proliferation is a hallmark of cancer. Purines are basic components of nucleotides in cell proliferation, thus impaired purine metabolism is associated with the progression of cancer. The de novo biosynthesis of purine depends on six enzymes to catalyze the conversion of phosphoribosylpyrophosphate to inosine 5'-monophosphate. These enzymes cluster around mitochondria and microtubules to form purinosome, which is a multi-enzyme complex involved in de novo purine biosynthesis and purine nucleotides requirement. In this review, we highlighted the purine metabolism and purinosom...

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