期刊论文

Liu, L

英文

Ticks and Tick-borne Diseases

1877-959X

2024

15

2

102289

10.1016/j.ttbdis.2023.102289

Natural Science Foundation of Hunan (Changsha, China) [2022JJ40169]; Science and Technology Innovation Program of Hunan Province (Changsha, China) [2022RC1161]; Science Fund for Distinguished Young Scholars of Changsha City, China (Changsha, China) [kq2206033]; Research Foundation of Education Bureau of Hunan Province (Changsha, China) [21A0133]

本校为第一且通讯机构

Ticks are blood-sucking ectoparasites that secrete immunomodulatory substances in saliva to hosts during engorging. Cystatins, a tick salivary protein and natural inhibitor of Cathepsins, are attracting growing interest globally because of the immunosuppressive activities and the feasibility as an antigen for developing anti-tick vaccines. This review outlines the classification and the structure of tick Cystatins, and focuses on the anti-inflammatory effects and molecular mechanisms. Tick Cystatins can be divided into four families based on st...