Modulation of gut homeostasis by exopolysaccharides from: Aspergillus cristatus (MK346334), a strain of fungus isolated from Fuzhuan brick tea, contributes to immunomodulatory activity in cyclophosphamide-treated mice

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成果类型：

期刊论文

作者：

Xie, Zhiyong;Bai, Yixuan;Chen, Guijie;Rui, Ying;Chen, Dan;...

通讯作者：

Zeng, Xiaoxiong;Liu, Zhonghua

作者机构：

[Chen, Guijie; Rui, Ying; Chen, Dan; Xie, Zhiyong; Zeng, Xiaoxiong; Bai, Yixuan; Sun, Yi] Nanjing Agr Univ, Coll Food Sci & Technol, Nanjing 210095, Jiangsu, Peoples R China.

[Liu, Zhonghua] Hunan Agr Univ, Minist Educ Tea Sci, Key Lab, Changsha 410128, Peoples R China.

[Liu, Zhonghua] Natl Res Ctr Engn Technol Utilizat Bot Funct Ingr, Changsha 410128, Peoples R China.

通讯机构：

[Zeng, Xiaoxiong; Liu, Zhonghua] N

[Liu, Zhonghua] H

Nanjing Agr Univ, Coll Food Sci & Technol, Nanjing 210095, Jiangsu, Peoples R China.

Hunan Agr Univ, Minist Educ Tea Sci, Key Lab, Changsha 410128, Peoples R China.

Natl Res Ctr Engn Technol Utilizat Bot Funct Ingr, Changsha 410128, Peoples R China.

语种：

英文

期刊：

FOOD & FUNCTION

ISSN：

2042-6496

年：

2020

卷：

期：

页码：

10397-10412

DOI：

10.1039/d0fo02272a

基金类别：

National Key Research and Development Program of China [2018YFC1604404]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2018M642265]; Priority Academic Program Development of Jiangsu Higher Education Institutions; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31972025]

机构署名：

本校为通讯机构

院系归属：

园艺园林学院

摘要：

In this study, the crude exopolysaccharides (CEPSs) from fungus Aspergillus cristatus (MK346334, NCBI) isolated from Fuzhuan brick tea and its main purified fraction (EPSs-2) were investigated. Using the RAW264.7 cell model, EPSs-2 exhibited an excellent immunomodulatory effect in vitro. Then, the regulating effects of EPSs on immune function and gut microbiota were evaluated using a cyclophosphamide (Cy)-induced mice model. It was found that both CEPSs and EPSs-2 improved the body weight loss, immune organ indexes as well as the levels of TNF-...

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Modulation of gut homeostasis by exopolysaccharides from: Aspergillus cristatus (MK346334), a strain of fungus isolated from Fuzhuan brick tea, contributes to immunomodulatory activity in cyclophosphamide-treated mice

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