Magnolol and honokiol attenuate apoptosis of enterotoxigenic escherichia coli-induced intestinal epithelium by maintaining secretion and absorption homeostasis and protecting mucosal integrity

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成果类型：

期刊论文

作者：

Deng, Yanli;Han, Xuefeng;Tang, Shaoxun;Li, Chengjian;Xiao, Wenjun*;...

通讯作者：

Xiao, Wenjun;Tan, Zhiliang

作者机构：

[Xiao, Wenjun; Deng, Yanli] Hunan Agr Univ, Natl Res Ctr Engn Technol Utilizat Bot Funct Ingr, Hunan Collaborat Innovat Ctr Utilizat Bot Funct I, Changsha, Hunan, Peoples R China.

[Deng, Yanli] Guizhou Univ, Tea Coll, Guiyang, Guizhou, Peoples R China.

[Tang, Shaoxun; Tan, Zhiliang; Han, Xuefeng] Chinese Acad Sci, Key Lab Agroecol Proc Subtrop Reg, Minist Agr, Inst Subtrop Agr, Changsha, Hunan, Peoples R China.

[Tang, Shaoxun; Tan, Zhiliang; Han, Xuefeng] Chinese Acad Sci, Minist Agr, Inst Subtrop Agr, South Cent Expt Stn Anim Nutr & Feed Sci, Changsha, Hunan, Peoples R China.

[Li, Chengjian] Yongzhou Vocat Tech Coll, Dept Pharm, Yongzhou, Hunan, Peoples R China.

通讯机构：

[Xiao, Wenjun] H

[Tan, Zhiliang] C

Hunan Agr Univ, Natl Res Ctr Engn Technol Utilizat Bot Funct Ingr, Hunan Collaborat Innovat Ctr Utilizat Bot Funct I, Changsha, Hunan, Peoples R China.

Chinese Acad Sci, Key Lab Agroecol Proc Subtrop Reg, Minist Agr, Inst Subtrop Agr, Changsha, Hunan, Peoples R China.

Chinese Acad Sci, Minist Agr, Inst Subtrop Agr, South Cent Expt Stn Anim Nutr & Feed Sci, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

dextro amino acid oxidase;gamma interferon;glucose;honokiol;inducible nitric oxide synthase;interleukin 10;lactic acid;loperamide;magnolol;messenger RNA;nitric oxide;autacoid;biphenyl derivative;cytokine;honokiol;lignan;magnolol;nitric oxide synthase;analytical parameters;animal experiment;animal model;animal tissue;apoptosis;Article;blood sampling;concentration (parameters);controlled study;crypt depth;diarrhea;Enterotoxigenic Escherichia coli induced diarrhea;Enterotoxigenic Escherichia coli induced diarrhea;enzyme activity;gastrointestinal absorption;goblet cell;high performance liquid chromatography;histopathology;immunohistochemistry;intestinal secretion;intestine mucosa;male;mouse;nonhuman;protein expression;ratio of villus height to crypt depth;real time polymerase chain reaction;RNA isolation;TUNEL assay;villus height;animal;apoptosis;drug effect;enterotoxigenic Escherichia coli;genetics;homeostasis;intestine absorption;metabolism;microbiology;oral drug administration;pathology;pathophysiology;Administration, Oral;Animals;Apoptosis;Biphenyl Compounds;Cytokines;Enterotoxigenic Escherichia coli;Homeostasis;Inflammation Mediators;Intestinal Absorption;Intestinal Mucosa;Lignans;Mice;Nitric Oxide Synthase

期刊：

MEDICAL SCIENCE MONITOR

ISSN：

1643-3750

年：

2018

卷：

页码：

3348-3356

DOI：

10.12659/MSM.910350

基金类别：

This study was financially supported by the National Natural Science Foundation of China (Grant number 30972166), Hunan Provincial Graduate Student Innovation Conditions (Grant number CX2011B304, CX2014B300), Hunan Provincial Science and Key Technology Project (Grant number 2017NK1020), and Hunan Provincial Natural Science Foundation of China (Grant number 2018JJ5052). Wenjun Xiao, e-mail: xiaowenjun88@sina.com, Zhiliang Tan, e-mail: zltan@isa.ac.cn This study was financially supported by the National Natural Science Foundation of China (Grant number 30972166), Hunan Provincial Graduate Student Innovation Conditions (Grant number CX2011B304, CX2014B300), Hunan Provincial Science and Key Technology Project (Grant number 2017NK1020), and Hunan Provincial Natural Science Foundation of China (Grant number 2018JJ5052)

机构署名：

本校为第一且通讯机构

院系归属：

园艺园林学院

摘要：

Background: The cortex of Magnolia officinalis has long been used as an element of traditional Chinese medicine for the treatment of anxiety, chronic bronchitis, and gastrointestinal dysfunction. This study aimed to elucidate the underlying mechanism of its functional ingredients (magnolol and honokiol) in modifying the secretion and absorption homeostasis and protecting mucosal integrity in an Enterotoxigenic Escherichia coli (ETEC)-induced diarrhea mouse model. Material/Methods: This study established a diarrhea mouse model infected by ETEC a...

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Magnolol and honokiol attenuate apoptosis of enterotoxigenic escherichia coli-induced intestinal epithelium by maintaining secretion and absorption homeostasis and protecting mucosal integrity

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