Biotransformation and tissue distribution of protopine and allocryptopine and effects of Plume Poppy Total Alkaloid on liver drug-metabolizing enzymes

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Huang, Ya-Jun;Cheng, Pi;Zhang, Zhuo-Yi;Tian, Shi-Jie;Sun, Zhi-Liang;...

通讯作者：

Liu, Zhao-Ying

作者机构：

[Tian, Shi-Jie; Sun, Zhi-Liang; Zeng, Jian-Guo; Liu, Zhao-Ying; Cheng, Pi; Huang, Ya-Jun] Hunan Agr Univ, Vet Herbal Med Resources & Initiat, Natl & Local Union Engn Res Ctr, Changsha 410128, Hunan, Peoples R China.

[Sun, Zhi-Liang; Liu, Zhao-Ying; Zhang, Zhuo-Yi; Huang, Ya-Jun] Hunan Agr Univ, Coll Vet Med, Hunan Engn Res Ctr ofVeterinary Drug, Changsha 410128, Hunan, Peoples R China.

[Zeng, Jian-Guo; Liu, Zhao-Ying] Hunan Agr Univ, Hunan Key Lab Tradit Chinese Vet Med, Changsha 410128, Hunan, Peoples R China.

通讯机构：

[Liu, Zhao-Ying] H

Hunan Agr Univ, Vet Herbal Med Resources & Initiat, Natl & Local Union Engn Res Ctr, Changsha 410128, Hunan, Peoples R China.

Hunan Agr Univ, Coll Vet Med, Hunan Engn Res Ctr ofVeterinary Drug, Changsha 410128, Hunan, Peoples R China.

Hunan Agr Univ, Hunan Key Lab Tradit Chinese Vet Med, Changsha 410128, Hunan, Peoples R China.

语种：

英文

期刊：

Scientific Reports

ISSN：

2045-2322

年：

2018

卷：

期：

页码：

537

DOI：

10.1038/s41598-017-18816-7

基金类别：

Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [2017JJ1017]; National Key R&D Program of China [2017YFD0501503]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31402109]

机构署名：

本校为第一且通讯机构

院系归属：

动物医学院

摘要：

In this study, the biotransformation in the plasma, urine and feces of rats following oral administration of protopine (PRO) and allocryptopine (ALL)were explored using HPLC-QqTOF MS. An HPLC-MS/MS method for the determination of tissues was developed and applied to the tissue distribution study in rats following intragastric administration of Plume Poppy Total Alkaloid for 3 weeks. A total of ten PRO metabolites and ten ALL metabolites were characterized in rats in vivo. Among these metabolites, six PRO metabolites and five ALL metabolites were reported for the first time. The predicated meta...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Biotransformation and tissue distribution of protopine and allocryptopine and effects of Plume Poppy Total Alkaloid on liver drug-metabolizing enzymes

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问