期刊论文

Wang, Naidong;Tian, Yanan

英文

TOXINS

2072-6651

2019

11

1

45-

10.3390/toxins11010045

Conceptualization, J.W., Y.Z., N.W. and Y.T.; methodology, J.W. and Y.Z.; validation, Y.Z. and J.W.; formal analysis, Y.Z. and J.W.; investigation, J.W. and Y.T.; resources, J.Y. and N.W.; data curation, Y.Z. and J.W.; writing—original draft preparation, Y.Z., J.W. and Y.T.; writing—review and editing, J.W., J.C. and Y.T.; visualization, Y.Z.; supervision, J.W., N.W. and J.Y.; project administration, Z.Y., J.Y. and J.W.; funding acquisition, N.W., J.Y. and J.W. This project was funded by the National Natural Science Foundation of China, grant number 31302157; the China Postdoctoral Science Foundation, grant number 2017M620346; the Scientific Research Fund of Hunan Provincial Education Department, grant numbers 17B125 and 15B114; and the Projects of Double-Class Initiative of Hunan Agricultural University, grant number KXK201801004.

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T-2 toxin is a mycotoxin generated by Fusarium species which has been shown to be highly toxic to human and animals. T-2 toxin induces apoptosis in various tissues/organs. Apoptosis and autophagy are two closely interconnected processes, which are important for maintaining physiological homeostasis as well as pathogenesis. Here, for the first time, we demonstrated that T-2 toxins induce autophagy in human liver cells (L02). We demonstrated that T-2 toxin induce acidic vesicular organelles formation, concomitant with the alterations in p62/SQSTM1 and LC3-phosphatidylethanolamine conjugate (LC3-...