Development of a sensitive and rapid UHPLC–MS/MS method for simultaneous quantification of nine compounds in rat plasma and application in a comparative pharmacokinetic study after oral administration of Xuefu Zhuyu Decoction and nimodipine

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成果类型：

期刊论文

作者：

Fu, Chunyan;Wu, Qian;Zhang, Zhimin;Xia, Zian;Liu, Zhaoying;...

通讯作者：

Lu, Hongmei;Wang, Yang

作者机构：

[Zhang, Zhimin; Lu, Hongmei; Fu, Chunyan; Wu, Qian] Cent South Univ, Coll Chem & Chem Engn, Changsha 410083, Hunan, Peoples R China.

[Fu, Chunyan] Shaoyang Univ, Coll Pharm, Shaoyang, Hunan, Peoples R China.

[Xia, Zian; Wang, Yang] Cent South Univ, Xiangya Hosp, Inst Integrated Tradit Chinese & Western Med, Lab Ethnopharmacol, Changsha 410008, Hunan, Peoples R China.

[Liu, Zhaoying] Hunan Agr Univ, Coll Vet Med, Hunan Engn Res Ctr Vet Drug, Changsha, Hunan, Peoples R China.

[Huang, Gang] Shimadzu Co Ltd, Guangzhou Analyt Applicat Ctr, Guangzhou, Peoples R China.

通讯机构：

[Lu, Hongmei; Wang, Yang] C

Cent South Univ, Coll Chem & Chem Engn, Changsha 410083, Hunan, Peoples R China.

Cent South Univ, Xiangya Hosp, Inst Integrated Tradit Chinese & Western Med, Lab Ethnopharmacol, Changsha 410008, Hunan, Peoples R China.

语种：

英文

关键词：

UHPLC-MS/MS;Xuefu Zhuyu Decoction;nimodipine;pharmacokinetics;rat plasma;traumatic brain injury

期刊：

Biomedical Chromatography

ISSN：

0269-3879

年：

2020

卷：

期：

页码：

e4872-

DOI：

10.1002/bmc.4872

基金类别：

Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [2019JJ30042]; Hunan Provincial Technology Innovation Guidance Plan, China [2018SK51902]; National Natural Scientific Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21675174, 21804142, 21873116, 81673719]

机构署名：

本校为其他机构

院系归属：

动物医学院

摘要：

Xuefu Zhuyu Decoction (XFZYD) is a traditional Chinese medicine prescription used for the clinical treatment of traumatic brain injury (TBI). The purpose of this work was to develop a sensitive and rapid UHPLC–MS/MS method to simultaneously study the pharmacokinetics of nimodipine and eight components of XFZYD, namely, amygdalin, hydroxysafflor yellow A, rutin, liquiritin, narirutin, naringin, neohesperidin and saikosaponin A, in rats with and without TBI. Multiple reaction monitoring was highly selective in the detection of nine analytes and ...

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Development of a sensitive and rapid UHPLC–MS/MS method for simultaneous quantification of nine compounds in rat plasma and application in a comparative pharmacokinetic study after oral administration of Xuefu Zhuyu Decoction and nimodipine

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