Plac1 Expression Pattern at the Mouse Fetomaternal Interface and Involvement in Trophoblast Differentiation

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成果类型：

期刊论文

作者：

Gu, Yanli;Wan, Junhui;Yao, Lv;Peng, Nan-Ni*;Chang, Wen-Lin*

通讯作者：

Peng, Nan-Ni;Chang, Wen-Lin

作者机构：

[Chang, Wen-Lin; Gu, Yanli; Yao, Lv] Peking Univ, Shenzhen Peking Univ Hong Kong Univ Sci & Technol, Guangdong & Shenzhen Key Lab Male Reprod Med & Ge, Inst Urol,Shenzhen Hosp,Biomed Res Inst, Shenzhen, Guangdong, Peoples R China.

[Wan, Junhui] Nanchang Univ, Affiliated Hosp 1, Dept Gynaecol & Obstet, Nanchang, Jiangxi, Peoples R China.

[Peng, Nan-Ni] Shenzen Univ, Affiliated Hosp 3, Reprod Med Ctr, Shenzhen, Guangdong, Peoples R China.

Hunan Agr Univ, Coll Vet Sci, Changsha, Hunan, Peoples R China.

[Peng, Nan-Ni; Chang, WL] Shenzhen Univ, Affiliated Hosp 3, Guangdong & Reprod Med Ctr, Guangdong & Shenzhen Key Lab Male Reprod Med & Ge, Shenzhen, Peoples R China.

通讯机构：

[Peng, NN; Chang, WL] S

Shenzhen Univ, Affiliated Hosp 3, Guangdong & Reprod Med Ctr, Guangdong & Shenzhen Key Lab Male Reprod Med & Ge, Shenzhen, Peoples R China.

语种：

英文

关键词：

Plac1;Spatiotemporal expression pattern;Fetomaternal interface;Trophoblast;Differentiation;Placenta

期刊：

Cellular Physiology and Biochemistry

ISSN：

1015-8987

年：

2018

卷：

期：

页码：

2001-2009

DOI：

10.1159/000484154

基金类别：

This study was supported by the grants from Basic Research projects of Shenzhen Science and Technology Innovation Committee, Shenzhen, Guangdong, China (JCYJ 球爃猃砃爃瘃球礃猃稃眃瘃爃猃甃砃瘁 JCYJ 球爃猃礃爃甃爃砃猃砃猃砃眃礃砃礃琂I.

机构署名：

本校为其他机构

院系归属：

动物医学院

摘要：

Background/Aims: It is well known that Plac1 is a placenta-specific gene; however, its spatiotemporal expression pattern and exact role at t h e mouse fetomaternal interface r e m a i n s unclear. Methods: In situ hybridization (ISH) was used to localize the Plac1 mRNA at the mouse fetomaternal interface. A trophoblast stem cell (TS) differentiation model with Plac1 shRNA-overexpressing lentivirus was employed to investigate the possible role of Plac1 in placentation. Real-time RT-PCR was used to detect changes in gene expression. Results: Plac...

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Plac1 Expression Pattern at the Mouse Fetomaternal Interface and Involvement in Trophoblast Differentiation

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