Mixed exposure to PFOA and PFOS induces oocyte apoptosis and subfertility in mice by activating the Hippo signaling pathway

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成果类型：

期刊论文

作者：

Yan, Xiang-Zhu;Peng, Jia;Liu, Yu-Qing;Fan, Ruo-Nan;Ni, Xin-Yi;...

通讯作者：

Tan, SH;Wang, HL

作者机构：

[Peng, Jia; Tan, Shu-Hua; Yan, Xiang-Zhu] Hunan Univ Sci & Technol, Coll Life Sci, Xiangtan 411201, Hunan, Peoples R China.

[Gong, Ling; Liu, Yu-Qing; Peng, Jia; Wang, HL; Wang, Hai-Long; Fan, Ruo-Nan; Ni, Xin-Yi; Yan, Xiang-Zhu; Zhang, Dan-Ni] Xiamen Univ, Sch Med, Dept Basic Med, Xiamen 361102, Fujian, Peoples R China.

[Gong, Ling; Fan, Ruo-Nan] Hunan Agr Univ, Coll Vet Med, Changsha 410128, Hunan, Peoples R China.

[Huang, Xin] Columbia Univ Irving Med Ctr, Columbia Ctr Human Dev & Stem Cell Therapies, Herbert Irving Comprehens Canc Ctr, Dept Med, New York, NY 10032 USA.

通讯机构：

[Wang, HL ] X

[Tan, SH ] H

Hunan Univ Sci & Technol, Coll Life Sci, Xiangtan 411201, Hunan, Peoples R China.

Xiamen Univ, Sch Med, Dept Basic Med, Xiamen 361102, Fujian, Peoples R China.

语种：

英文

关键词：

Apoptosis;Fertility;Hippo signaling pathway;Mouse oocyte;PFOA and PFOS mixture

期刊：

Reproductive Toxicology

ISSN：

0890-6238

年：

2025

卷：

132

页码：

108829

DOI：

10.1016/j.reprotox.2024.108829

基金类别：

CRediT authorship contribution statement Shu-Hua Tan: Writing – review & editing, Validation, Supervision, Methodology, Conceptualization. Hai-Long Wang: Writing – review & editing, Validation, Supervision, Project administration, Methodology, acquisition. Xiang-Zhu Yan: Writing – original draft, Formal analysis, Data curation. Jia Peng: Writing – review & editing, Formal analysis, Data curation. Yu-Qing Liu: Writing – review & editing, Software, Formal analysis. Ruo-Nan Fan: Writing – review & editing, Software, Funding

机构署名：

本校为其他机构

院系归属：

动物医学院

摘要：

Per- and polyfluoroalkyl substances (PFAS) are synthetic perfluorinated compounds known for their persistence in the environment and reproduction toxicity. PFAS, perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS), have been identified in the follicular fluid of infertile women. However, the specific of PFOA and PFOS mixture on oocyte quality and female fertility remain unclear. In this study, we exposed female mice to combination of PFOA and PFOS to investigate the underlying mechanisms impairing fertility and oocyte maturation. Our results showed that exposure to the mixture i...

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Mixed exposure to PFOA and PFOS induces oocyte apoptosis and subfertility in mice by activating the Hippo signaling pathway

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