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l-Theanine attenuates liver aging by inhibiting advanced glycation end products in d-galactose-induced rats and reversing an imbalance of oxidative stress and inflammation

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成果类型:
期刊论文
作者:
Zeng, Li;Lin, Ling;Peng, Yingqi;Yuan, Dongyin;Zhang, Sheng;...
通讯作者:
Gong, Zhihua;Xiao, Wenjun
作者机构:
[Yuan, Dongyin; Zeng, Li; Gong, Zhihua; Gong, ZH; Xiao, WJ; Xiao, Wenjun; Peng, Yingqi; Zhang, Sheng; Lin, Ling] Hunan Agr Univ, Natl Res Ctr Engn & Technol Utilizat Bot Funct In, Changsha 410128, Peoples R China.
[Zeng, Li] Shaoyang Univ, Sch Pharm, Shaoyang 422000, Peoples R China.
[Yuan, Dongyin; Zeng, Li; Gong, Zhihua; Xiao, Wenjun; Peng, Yingqi; Zhang, Sheng; Lin, Ling] Hunan Agr Univ, Key Lab Tea Sci, Minist Educ, Changsha 410128, Hunan, Peoples R China.
通讯机构:
[Gong, ZH; Xiao, WJ] H
Hunan Agr Univ, Natl Res Ctr Engn & Technol Utilizat Bot Funct In, Changsha 410128, Peoples R China.
语种:
英文
关键词:
AGEs;Inflammatory response;Liver aging;Oxidative stress;l-Theanine
期刊:
Experimental Gerontology
ISSN:
0531-5565
年:
2020
卷:
131
页码:
110823
基金类别:
This work was financially supported by the National Natural Science Foundation of China [grant number 31871804 ]; Science and Technology Major Project of Changsha , China [grant number kq1804003 ]; the Natural Science Foundation of Hunan Province , China [grant number 2019JJ40272 ]; and the Scientific Research Foundation of Hunan Provincial Education Department , China [grant number 18C0808 ]. We would like to thank Editage ( http://online.editage.cn/ ) for English language editing.
机构署名:
本校为第一且通讯机构
院系归属:
园艺园林学院
摘要:
Redox and inflammation imbalances are associated with increased levels of advanced glycation end products (AGEs), leading to the degeneration of body function. L-Theanine, derived from tea, reportedly inhibits AGE formation in vitro. We investigated the effects on AGE content, oxidative stress, and inflammatory factors in D-galactose-induced aging rats for prevention and treatment of age-related liver dysfunction. L-Theanine increased activities of antioxidant enzymes such as superoxide dismutase, catalase, and glutathione peroxidase, thus enhancing total antioxidant capacity, and decreasing m...

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