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Identification of miR-124a as a novel diagnostic and prognostic biomarker in non-small cell lung cancer for chemotherapy

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成果类型:
期刊论文
作者:
Luo, Pei;Yang, Qing;Cong, Le-Le;Wang, Xiao-Feng;Li, Yu-Sheng;...
通讯作者:
Ma, Yu-Shui;Zeng, Qing-Hua
作者机构:
[Luo, Pei; Yang, Hui-Qiong; Xie, Ru-Ting; Li, Wen-Ping; Yang, Qing] Hunan Agr Univ, Coll Vet Med, Changsha 410128, Hunan, Peoples R China.
[Cong, Le-Le] Jilin Univ, China Japan Union Hosp, Dept Neurol, Changchun 130031, Jilin, Peoples R China.
[Xia, Qing; Wang, Xiao-Feng] Fudan Univ, Zhongshan Hosp, Dept Orthoped, Shanghai 200032, Peoples R China.
[Li, Yu-Sheng] Cent S Univ, Xiangya Hosp, Dept Orthoped, Changsha 410008, Hunan, Peoples R China.
[Zhong, Xiao-Ming] Jiangxi Prov Tumor Hosp, Dept Radiol, Nanchang 330029, Jiangxi, Peoples R China.
通讯机构:
[Ma, Yu-Shui] T
[Zeng, Qing-Hua] N
Tongji Univ, Shanghai Peoples Hosp 10, Dept Nucl Med, Sch Med, 301 Yanchang Rd, Shanghai 200072, Peoples R China.
Nanchang Univ, Affiliated Hosp 1, Dept Resp, 17 Yongwaizheng Rd, Nanchang 330006, Jiangxi, Peoples R China.
语种:
英文
关键词:
antineoplastic agent;microRNA;microRNA 124a;tumor marker;unclassified drug;microRNA;MIRN124 microRNA, human;tumor marker;A-549 cell line;adult;aged;Article;cancer chemotherapy;cancer diagnosis;cancer prognosis;cancer size;cancer staging;cancer survival;controlled study;disease free survival;female;gene expression;human;human tissue;lung cancer cell line;lymph node metastasis;major clinical study;male;non small cell lung cancer;overall survival;reverse transcription polymerase chain reaction;RNA extraction;tumor biopsy;tumor differentiation;biology;cancer grading;gene expression regulation;genetics;Kaplan Meier method;lung tumor;metastasis;middle aged;mortality;non small cell lung cancer;nucleic acid database;procedures;prognosis;proportional hazards model;tumor cell line;Adult;Aged;Biomarkers, Tumor;Carcinoma, Non-Small-Cell Lung;Cell Line, Tumor;Computational Biology;Databases, Nucleic Acid;Female;Gene Expression Regulation, Neoplastic;Humans;Kaplan-Meier Estimate;Lung Neoplasms;Male;MicroRNAs;Middle Aged;Neoplasm Grading;Neoplasm Metastasis;Neoplasm Staging;Prognosis;Proportional Hazards Models
期刊:
MOLECULAR MEDICINE REPORTS
ISSN:
1791-2997
年:
2017
卷:
16
期:
1
页码:
238-246
基金类别:
The present study was partially supported by grants from the National Natural Science Foundation of China (grant nos. 81201535, 81472202 and 81302065), Shanghai Natural Science Foundation (grant nos. 12ZR1436000 and 16ZR1428900) and Shanghai Municipal Commission of Health and Family Planning (grant nos. 201440398 and 201540228), Jiangxi Province Department of Science Plan Funded Projects (grant no. 2011BBG70046), Hunan Natural Science Fund for Distinguished Young Scholars Project (grant no. 2015JJ1009) and the Jilin Provincial Science and Technology Department (grant nos. 20130727029YY, 20140f14061GH and 20150204057SF).
机构署名:
本校为第一机构
院系归属:
动物医学院
摘要:
Previous studies have suggested that dysregulation of microRNA (miR) -124a is associated with various types of human cancer. However, there are few studies reporting the level of miR-124a expression in non-small cell lung cancer (NSCLC). The present study investigated the association between miR-124a and NSCLC by analyzing the differential expression of miR-124a in NSCLC using the GEO database, as well as subsequently performing reverse transcription-quantitative polymerase chain reaction analysis on 160 NSCLC biopsies, 32 of which were paired with adjacent normal tissues. The results indicate...

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