Identification of miR-124a as a novel diagnostic and prognostic biomarker in non-small cell lung cancer for chemotherapy

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成果类型：

期刊论文

作者：

Luo, Pei;Yang, Qing;Cong, Le-Le;Wang, Xiao-Feng;Li, Yu-Sheng;...

通讯作者：

Ma, Yu-Shui;Zeng, Qing-Hua

作者机构：

[Luo, Pei; Yang, Hui-Qiong; Xie, Ru-Ting; Li, Wen-Ping; Yang, Qing] Hunan Agr Univ, Coll Vet Med, Changsha 410128, Hunan, Peoples R China.

[Cong, Le-Le] Jilin Univ, China Japan Union Hosp, Dept Neurol, Changchun 130031, Jilin, Peoples R China.

[Xia, Qing; Wang, Xiao-Feng] Fudan Univ, Zhongshan Hosp, Dept Orthoped, Shanghai 200032, Peoples R China.

[Li, Yu-Sheng] Cent S Univ, Xiangya Hosp, Dept Orthoped, Changsha 410008, Hunan, Peoples R China.

[Zhong, Xiao-Ming] Jiangxi Prov Tumor Hosp, Dept Radiol, Nanchang 330029, Jiangxi, Peoples R China.

通讯机构：

[Ma, Yu-Shui] T

[Zeng, Qing-Hua] N

Tongji Univ, Shanghai Peoples Hosp 10, Dept Nucl Med, Sch Med, 301 Yanchang Rd, Shanghai 200072, Peoples R China.

Nanchang Univ, Affiliated Hosp 1, Dept Resp, 17 Yongwaizheng Rd, Nanchang 330006, Jiangxi, Peoples R China.

语种：

英文

关键词：

microRNA-124;non-small cell lung cancer;chemotherapy;overall survival;disease-free survival;biomarker;prognosis

期刊：

MOLECULAR MEDICINE REPORTS

ISSN：

1791-2997

年：

2017

卷：

期：

页码：

238-246

DOI：

10.3892/mmr.2017.6595

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81201535, 81472202, 81302065]; Shanghai Natural Science FoundationNatural Science Foundation of Shanghai [12ZR1436000, 16ZR1428900]; Shanghai Municipal Commission of Health and Family Planning [201440398, 201540228]; Jiangxi Province Department of Science Plan [2011BBG70046]; Hunan Natural Science Fund for Distinguished Young Scholars Project [2015JJ1009]; Jilin Provincial Science and Technology Department [20130727029YY, 20140f14061GH, 20150204057SF]

机构署名：

本校为第一机构

院系归属：

动物医学院

摘要：

Previous studies have suggested that dysregulation of microRNA (miR) -124a is associated with various types of human cancer. However, there are few studies reporting the level of miR-124a expression in non-small cell lung cancer (NSCLC). The present study investigated the association between miR-124a and NSCLC by analyzing the differential expression of miR-124a in NSCLC using the GEO database, as well as subsequently performing reverse transcription-quantitative polymerase chain reaction analysis on 160 NSCLC biopsies, 32 of which were paired with adjacent normal tissues. The results indicate...

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Identification of miR-124a as a novel diagnostic and prognostic biomarker in non-small cell lung cancer for chemotherapy

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