Comprehensive Analysis of the Transcriptome-Wide m6A Methylome in Shaziling Pig Testicular Development - 成果

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Comprehensive Analysis of the Transcriptome-Wide m⁶A Methylome in Shaziling Pig Testicular Development

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Chen, Chujie;Tang, Xiangwei;Yan, Saina;Yang, Anqi;Xiang, Jiaojiao;...

通讯作者：

Chen, Bin;Gu, JJ

作者机构：

[Chen, Chujie; Tang, Xiangwei; Yan, Saina; Gu, JJ; Deng, Yanhong; Yang, Anqi; Chen, Bin; Yin, Yulong; Gu, Jingjing; Xiang, Jiaojiao] Hunan Agr Univ, Coll Anim Sci & Technol, Changsha 410128, Peoples R China.

[Chen, Chujie; Tang, Xiangwei; Yan, Saina; Gu, JJ; Deng, Yanhong; Yang, Anqi; Chen, Bin; Gu, Jingjing; Xiang, Jiaojiao] Hunan Agr Univ, Hunan Prov Key Lab Genet Improvement Domest Anim, Changsha 410128, Peoples R China.

[Yin, Yulong] Chinese Acad Sci, Key Lab Agroecol Proc Subtrop Reg, Inst Subtrop Agr, Changsha 410125, Peoples R China.

通讯机构：

[Gu, JJ ; Chen, B] H

Hunan Agr Univ, Coll Anim Sci & Technol, Changsha 410128, Peoples R China.

Hunan Agr Univ, Hunan Prov Key Lab Genet Improvement Domest Anim, Changsha 410128, Peoples R China.

语种：

英文

关键词：

mRNA m(6)A methylation;testis;ALKBH5;SOX9;Shaziling pig

期刊：

International Journal of Molecular Sciences

ISSN：

1661-6596

年：

2023

卷：

期：

DOI：

10.3390/ijms241914475

基金类别：

key R&D project from Hunan Province [2020NK2024]; earmarked fund for the Hunan Provincial Modern Agro-Industry Technology Research System; Hunan Provincial Natural Science Foundation of China [2020JJ4348]

机构署名：

本校为第一且通讯机构

院系归属：

动物科学技术学院

摘要：

RNA N6-methyladenosine (m(6)A ) modification is one of the principal post-transcriptional modifications and plays a dynamic role in testicular development and spermatogenesis. However, the role of m(6)A in porcine testis is understudied. Here, we performed a comprehensive analysis of the m(6)A transcriptome-wide profile in Shaziling pig testes at birth, puberty, and maturity. We analyzed the total transcriptome m(6)A profile and found that the m(6)A patterns were highly distinct in terms of the modification of the transcriptomes during porcine testis development. We found that key m(6)A methyl...

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