Comprehensive analysis of IGF2BP3 with expression features, prognosis, immune modulation and stemness in hepatocellular carcinoma and pan-cancer

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成果类型：

期刊论文

作者：

Qin, Sha;Jin, Haoer;Li, Yan;Chen, Xue;He, Jiang;...

通讯作者：

Zhao, LQ

作者机构：

[Zhao, LQ; Li, Yan; Zhao, Luqing; Qin, Sha; Jin, Haoer] Cent South Univ, Xiangya Hosp, Dept Pathol, Changsha, Hunan, Peoples R China.

[Li, Yan; Zhao, Luqing; Qin, Sha; Jin, Haoer] Cent South Univ, Sch Basic Med Sci, Xiangya Sch Med, Dept Pathol, Changsha, Hunan, Peoples R China.

[Chen, Xue] Cent South Univ, Hunan Canc Hosp, Early Clin Trial Ctr, Xiangya Sch Med, Changsha, Hunan, Peoples R China.

[Chen, Xue] Cent South Univ, Affiliated Canc Hosp, Xiangya Sch Med, Changsha, Hunan, Peoples R China.

[He, Jiang] Cent South Univ, Xiangya Hosp, Ctr Mol Med, Changsha, Hunan, Peoples R China.

通讯机构：

[Zhao, LQ ] C

Cent South Univ, Xiangya Hosp, Dept Pathol, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

IGF2BP3;expression features;hepatocellular carcinoma (HCC);immune modulation;pan-cancer analysis.;prognosis

期刊：

JOURNAL OF CANCER

ISSN：

1837-9664

年：

2024

卷：

期：

页码：

2845-2865

DOI：

10.7150/jca.92768

基金类别：

Natural Science Foundation of Hunan Province [2022JJ30794]; Changsha Municipal Natural Science Foundation [kq2202126]; Research Project on Teaching Reform in Ordinary Higher Education Institutions in Hunan Province [HNJG-20230120]; Graduate Education and Teaching Reform Project of Central South University [2022YJSKS018, 2023JGB118, 2023jy153, 2024ALK005]

机构署名：

本校为其他机构

院系归属：

生物科学技术学院

摘要：

Insulin like growth factor 2 mRNA binding protein 3 (IGF2BP3) is a critical m6A reader. It encodes proteins that contain several KH domains, which are important in RNA binding, RNA synthesis and metabolism. Lots of researches have studied the malignant potential of m6A readers in tumors. However, the biological functional analysis of IGF2BP3 in hepatocellular carcinoma (HCC) and pan-cancer is not comprehensive. In this study, we used a bioinformatics approach to comprehensively analyze the significance of IGF2BP3 in HCC through analyzing its ex...

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Comprehensive analysis of IGF2BP3 with expression features, prognosis, immune modulation and stemness in hepatocellular carcinoma and pan-cancer

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