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Comprehensive analysis of IGF2BP3 with expression features, prognosis, immune modulation and stemness in hepatocellular carcinoma and pan-cancer.

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成果类型:
期刊论文
作者:
Qin, Sha;Jin, Haoer;Li, Yan;Chen, Xue;He, Jiang;...
作者机构:
[Li, Yan; Zhao, Luqing; Qin, Sha; Jin, Haoer] Department of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan, China
[Li, Yan; Zhao, Luqing; Qin, Sha; Jin, Haoer] and Department of Pathology, School of Basic Medical Science, Xiangya School of Medicine, Central South University, Changsha, Hunan, China
[Chen, Xue] Early Clinical Trial Center, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China
[He, Jiang] Center for Molecular Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China
[Qin, Yan; Xiao, Juxiong; Mao, Yitao] Department of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan, China
语种:
英文
关键词:
IGF2BP3;expression features;hepatocellular carcinoma (HCC);immune modulation;pan-cancer analysis.;prognosis
期刊:
JOURNAL OF CANCER
ISSN:
1837-9664
年:
2024
卷:
15
期:
9
页码:
2845-2865
机构署名:
本校为其他机构
院系归属:
生物科学技术学院
摘要:
Insulin like growth factor 2 mRNA binding protein 3 (IGF2BP3) is a critical m6A reader. It encodes proteins that contain several KH domains, which are important in RNA binding, RNA synthesis and metabolism. Lots of researches have studied the malignant potential of m6A readers in tumors. However, the biological functional analysis of IGF2BP3 in hepatocellular carcinoma (HCC) and pan-cancer is not comprehensive. In this study, we used a bioinformatics approach to comprehensively analyze the significance of IGF2BP3 in HCC through analyzing its expression, mutation, prognosis, protein-protein int...

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