N6-Methyladenine DNA Modification in the Human Genome

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Xiao, Chuan-Le;Zhu, Song;He, Minghui;Chen, De;Zhang, Qian;...

通讯作者：

Yan, Guang-Rong;Gu, Xiao-Feng;Bo, Xiao-Chen;Wang, Kai

作者机构：

[Zhu, Song; Chen, De; Xiao, Chuan-Le; Yan, Guang-Rong] Guangzhou Med Univ, Affiliated Hosp 3, Biomed Res Ctr, Guangzhou 510150, Guangdong, Peoples R China.

[Xie, Shang-Qian; Chen, Ying; Xiao, Chuan-Le] Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou 510060, Guangdong, Peoples R China.

[Xiao, Chuan-Le] Hunan Agr Univ, Coll Plant Protect, Changsha 410128, Hunan, Peoples R China.

[Liu, Jinbao; Zhu, Song; Chen, De; Yan, Guang-Rong] Guangzhou Med Univ, Sch Basic Med Sci, Key Lab Prot Modificat & Degradat, Guangzhou 511436, Guangdong, Peoples R China.

[He, Minghui] CookGene Biosci Ctr, Guangzhou 510320, Guangdong, Peoples R China.

通讯机构：

[Yan, Guang-Rong] G

[Gu, Xiao-Feng; Wang, Kai] C

[Bo, Xiao-Chen] B

Guangzhou Med Univ, Affiliated Hosp 3, Biomed Res Ctr, Guangzhou 510150, Guangdong, Peoples R China.

Guangzhou Med Univ, Sch Basic Med Sci, Key Lab Prot Modificat & Degradat, Guangzhou 511436, Guangdong, Peoples R China.

语种：

英文

关键词：

6mA;cancer;demethylase;human genome;m6A;methylation;methyltransferase

期刊：

Molecular Cell

ISSN：

1097-2765

年：

2018

卷：

期：

页码：

306-318.e7

DOI：

10.1016/j.molcel.2018.06.015

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81772998, 81672393]; R&D Plan of Guangzhou and Guangdong [201704020115, 2017A020215096]; Ministry of Education of Guangzhou [1201561583]; Innovative Research Team of Ministry of Education of Guangzhou [1201610015]; National Funds of Developing Local Colleges and Universities [B16056001]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [15ykjc23d]; Guangdong Natural Science FoundationNational Natural Science Foundation of Guangdong Province [2015A030313127]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2017M612798]; NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [HG006465]

机构署名：

本校为其他机构

院系归属：

植物保护学院

摘要：

DNA N 6 -methyladenine (6mA) modification is the most prevalent DNA modification in prokaryotes, but whether it exists in human cells and whether it plays a role in human diseases remain enigmatic. Here, we showed that 6mA is extensively present in the human genome, and we cataloged 881,240 6mA sites accounting for ∼0.051% of the total adenines. [G/C]AGG[C/T] was the most significantly associated motif with 6mA modification. 6mA sites were enriched in the coding regions and mark actively transcribed genes in human cells. DNA 6mA and N 6 -demet...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

N6-Methyladenine DNA Modification in the Human Genome

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问