Protective Effect and Mechanism of L-Theanine on Acute Alcoholic Liver Injury in Mice

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成果类型：

期刊论文

作者：

Liu, Meng-Yuan;Xu, Kai-Hang;Liu, Sha;Xiao, Wen-Jun

通讯作者：

Xiao, WJ

作者机构：

[Xiao, Wen-Jun; Xiao, WJ; Liu, Sha; Xu, Kai-Hang; Liu, Meng-Yuan] Hunan Agr Univ, Key Lab Tea Sci, Minist Educ, Changsha 410128, Hunan, Peoples R China.

[Xiao, Wen-Jun; Xiao, WJ; Liu, Sha; Xu, Kai-Hang; Liu, Meng-Yuan] Hunan Agr Univ, Natl Res Ctr Engn & Technol Utilizat Bot Funct Ing, Changsha 410128, Hunan, Peoples R China.

[Xiao, Wen-Jun; Xiao, WJ; Liu, Sha; Xu, Kai-Hang; Liu, Meng-Yuan] Hunan Agr Univ, Sino Kenya Joint Lab Tea Sci, Changsha 410128, Hunan, Peoples R China.

通讯机构：

[Xiao, WJ ] H

Hunan Agr Univ, Key Lab Tea Sci, Minist Educ, Changsha 410128, Hunan, Peoples R China.

Hunan Agr Univ, Natl Res Ctr Engn & Technol Utilizat Bot Funct Ing, Changsha 410128, Hunan, Peoples R China.

Hunan Agr Univ, Sino Kenya Joint Lab Tea Sci, Changsha 410128, Hunan, Peoples R China.

语种：

英文

关键词：

L‐theanine;acute alcoholic liver injury;alcohol metabolism;inflammatory response;oxidative stress

期刊：

Molecular nutrition & food research

ISSN：

1613-4125

年：

2024

页码：

e2400766

DOI：

10.1002/mnfr.202400766

基金类别：

National Key Research and Development Program of China; Key R&D Program of Hunan Province [2021NK1020]; [2022YFD1600805]

机构署名：

本校为第一且通讯机构

院系归属：

园艺园林学院

摘要：

L‐theanine found in tea leaves helps protect the liver from damage caused by excessive alcohol consumption. It accelerates alcohol metabolism by increasing the expression of related enzymes, reduces the accumulation of harmful substances like reactive oxygen species by inhibiting CYP2E1 and enhancing antioxidant enzyme activity, and alleviates liver inflammation by modulating the TNF‐α/NF‐κB pathway, thus minimizing liver damage. Abstract Scope Acute alcoholic liver injury (AALI), a global health concern, is exacerbated by excessive episod...

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Protective Effect and Mechanism of L-Theanine on Acute Alcoholic Liver Injury in Mice

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