Exploration of the Peptide Recognition of an Amiloride-sensitive FMRFamide Peptide-gated Sodium Channel

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成果类型：

期刊论文

作者：

Niu, You-Ya;Yang, Yang;Liu, Yan;Huang, Li-Dong;Yang, Xiao-Na;...

通讯作者：

Tian, Yun;Yu, Ye

作者机构：

[Tian, Yun; Niu, You-Ya; Lu, Xiang-Yang; Yu, Ye; Yang, Xiao-Na; Tian, Y] Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Hunan, Peoples R China.

[Niu, You-Ya; Hu, You-Min; Yang, Yang; Liu, Yan; Yu, Ye; Cheng, Xiao-Yang; Yang, Xiao-Na; Huang, Li-Dong] Shanghai Jiao Tong Univ, Sch Med, Inst Med Sci, Shanghai 200025, Peoples R China.

[Niu, You-Ya; Hu, You-Min; Yang, Yang; Liu, Yan; Yu, Ye; Cheng, Xiao-Yang; Yang, Xiao-Na; Huang, Li-Dong] Shanghai Jiao Tong Univ, Sch Med, Dept Pharmacol, Shanghai 200025, Peoples R China.

[Niu, You-Ya; Hu, You-Min; Yang, Yang; Liu, Yan; Yu, Ye; Cheng, Xiao-Yang; Yang, Xiao-Na; Huang, Li-Dong] Shanghai Jiao Tong Univ, Sch Med, Dept Physiol, Shanghai 200025, Peoples R China.

[Fan, Ying-Zhe] Shanghai Univ Chinese Tradit Med, Putuo Dist Ctr Hosp, Shanghai 200062, Peoples R China.

通讯机构：

[Tian, Y; Yu, Y] H

[Yu, Ye] S

Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Hunan, Peoples R China.

Shanghai Jiao Tong Univ, Sch Med, Inst Med Sci, Shanghai 200025, Peoples R China.

Shanghai Jiao Tong Univ, Sch Med, Dept Pharmacol, Shanghai 200025, Peoples R China.

语种：

英文

关键词：

FMRFamide (Phe-Met-Arg-Phe-NH2) peptides;FaNaC channels;channel gating;epithelial sodium channel (ENaC);ion channel;ligand-binding protein;ligand-recognition;neuropeptide;peptide interaction

期刊：

Journal of Biological Chemistry

ISSN：

0021-9258

年：

2016

卷：

291

期：

页码：

7571-7582

DOI：

10.1074/jbc.M115.710251

基金类别：

National Excellent Young Scientist Foundation of China [31222018]; National Program on Key Basic Research Project of ChinaNational Basic Research Program of China [2014CB910302]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31170787, 31570832, 31400707, 81302694, 81473377]; National Key Laboratory of Receptors [SIMM1601KF-02]; Shanghai Jiao Tong University-SMC Mutual Funds for Excellent Young Scholar [2013SMC-A-7]; Shanghai Jiao Tong University School of Medicine-Key Incubation Project [12x190030017]; Key National SAMP;T Program "Major New Drug Development" Grant [2012ZX09504001-003]; Science and Technology Fund of Shanghai Jiao Tong University School of Medicine [13XJ10042]

机构署名：

本校为第一且通讯机构

院系归属：

生物科学技术学院

摘要：

FMRFamide (Phe-Met-Arg-Phe-NH2)- Activated sodium channel (FaNaC) is an amiloride-sensitive sodium channel activated by endogenous tetrapeptide in invertebrates, and belongs to the epithelial sodium channel/degenerin (ENaC/DEG) superfamily. The ENaC/DEG superfamily differs markedly in its means of activation, such as spontaneously opening or gating by mechanical stimuli or tissue acidosis. Recently, it has been observed that a number of ENaC/DEG channels can be activated by small molecules or peptides, indicating that the ligand-gating may be an important feature of this superfamily. The pepti...

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Exploration of the Peptide Recognition of an Amiloride-sensitive FMRFamide Peptide-gated Sodium Channel

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