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Bilberry anthocyanins ameliorate NAFLD by improving dyslipidemia and gut microbiome dysbiosis

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成果类型:
期刊论文
作者:
Nakano, Hironobu;Wu, Shusong;Sakao, Kozue;Hara, Taichi;He, Jianhua;...
通讯作者:
Hou, De-Xing
作者机构:
[Sakao, Kozue; Nakano, Hironobu; Hou, De-Xing] Kagoshima Univ, Grad Sch Agr, Kagoshima 8900065, Japan.
[Wu, Shusong; He, Jianhua] Hunan Agr Univ, Coll Anim Sci & Technol, Changsha 410128, Peoples R China.
[Sakao, Kozue; Hou, De-Xing] Kagoshima Univ, United Grad Sch Agr Sci, Kagoshima 8900065, Japan.
[Hara, Taichi] Waseda Univ, Fac Human Sci, 2-579-15 Mikajima, Tokorozawa, Saitama 3591192, Japan.
[Garcia, Santos] Univ Autonoma Nuevo Leon, Fac Biol C, San Nicolas 66451, Mexico.
通讯机构:
[Hou, De-Xing] K
Kagoshima Univ, Grad Sch Agr, Kagoshima 8900065, Japan.
Kagoshima Univ, United Grad Sch Agr Sci, Kagoshima 8900065, Japan.
语种:
英文
关键词:
acetic acid;alanine aminotransferase;alpha smooth muscle actin;anthocyanin;aspartate aminotransferase;butyric acid;cholesterol;glucose;insulin;kelch like ECH associated protein 1;lactic acid;lipid;low density lipoprotein cholesterol;manganese superoxide dismutase;monocyte chemotactic protein 1;propionic acid;RNA 16S;thiobarbituric acid reactive substance;transcription factor Nrf2;triacylglycerol;alanine aminotransferase;anthocyanin;aspartate aminotransferase;low density lipoprotein cholesterol;RNA 16S;Akkermansia;alanine aminotransferase blood level;animal experiment;animal model;animal tissue;Article;aspartate aminotransferase blood level;bacterial microbiome;Bacteroidetes;bilberry;cecum;cholesterol blood level;controlled study;drug mechanism;dysbiosis;dyslipidemia;fat content;Firmicutes;glucose blood level;inflammation;insulin blood level;insulin resistance;intestine flora;lipid storage;male;mouse;nonalcoholic fatty liver;nonhuman;oxidative stress;Parabacteroides;RNA sequencing;triacylglycerol blood level;adverse event;animal;bilberry;blood;chemistry;complication;dietary supplement;disease model;dysbiosis;dyslipidemia;genetics;intestine flora;liver;metabolic syndrome X;metabolism;microbiology;nonalcoholic fatty liver;Western diet;Alanine Transaminase;Animals;Anthocyanins;Aspartate Aminotransferases;Cholesterol, LDL;Diet, Western;Dietary Supplements;Disease Models, Animal;Dysbiosis;Dyslipidemias;Gastrointestinal Microbiome;Liver;Metabolic Syndrome;Mice;Non-alcoholic Fatty Liver Disease;RNA, Ribosomal, 16S;Vaccinium myrtillus
期刊:
Nutrients
ISSN:
2072-6643
年:
2020
卷:
12
期:
11
页码:
1-16
基金类别:
Funding: This research was supported by Grant-in-Aid for scientific research (C) of the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan to D.-X.H. (20K05928), and the Scholar Research of Kagoshima University Fund to D.-X.H. (70030117).
机构署名:
本校为其他机构
院系归属:
动物科学技术学院
摘要:
Non-alcoholic fatty liver disease (NAFLD) is a manifestation of metabolic syndrome closely linked to dyslipidemia and gut microbiome dysbiosis. Bilberry anthocyanins (BA) have been reported to have preventive effects against metabolic syndrome. This study aimed to investigate the protective effects and mechanisms of BA in aWestern diet (WD)-induced mouse model. The results revealed that supplementation with BA attenuated the serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), low-density lipoprotein cholesterol (LD...

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