O-GLCNAC TRANSFERASE PROMOTES INFLUENZA A VIRUS-INDUCED CYTOKINE STORM BY TARGETING INTERFERON REGULATORY FACTOR-5

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Wang, Qiming;Fang, Peining;He, Rui;Li, Mengqi;Yu, Haisheng;...

通讯作者：

Liu, Shi

作者机构：

[Peng, Guoping; Wang, Qiming; Rao, Liqun] Human Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Human Province, Peoples R China.

[He, Rui; Zhu, Ying; Peng, Nanfang; Liu, Shi; Fang, Peining; Zhou, Li; Yu, Haisheng; Li, Mengqi] Wuhan Univ, Coll Life Sci, Modern Virol Res Ctr, State Key Lab Virol, Wuhan 430072, Peoples R China.

[Yi, Yu] Zhejiang Univ, Minist Educ & Innovat, Ctr Cell Signaling Network, Life Sci Inst,Key Lab Biosyst Homeostasis & Prote, Hangzhou, Zhejiang, Peoples R China.

[Rong, Yuan; Wang, Fubing] Wuhan Univ, Zhongnan Hosp, Dept Lab Med, Wuhan, Peoples R China.

[Zhang, Yi] Hubei Univ Technol, Coll Food & Pharmaceut Engn, Hubei Prov Cooperat Innovat Ctr Ind Fermentat, Wuhan 430068, Peoples R China.

通讯机构：

[Liu, Shi] W

Wuhan Univ, Coll Life Sci, Modern Virol Res Ctr, State Key Lab Virol, Wuhan 430072, Peoples R China.

语种：

英文

期刊：

Science Advances

ISSN：

2375-2548

年：

2020

卷：

期：

DOI：

10.1126/sciadv.aaz7086

基金类别：

Foundation for Innovative Research Groups of the National Natural Science Foundation of China#&#&#81872262 to Shi Liu, 31570870 to Ying Zhu, 81301428 to Li Zhou and 81802627 to Yi Yu the Fundamental Research Funds for the Central Universities#&#&#2042017kf0221 to Shi Liu, 2042015kf0188 to Li Zhou the Deutsche Forschungsgemeinschaft#&#&#TRR60 and RTG1949 to Mengji Lu and Mirko Trilling Science and Technology Innovation Fostering Foundation of Zhongnan Hospital of Wuhan University#&#&#cxpy20160025 to Fubing Wang

机构署名：

本校为第一机构

院系归属：

生物科学技术学院

摘要：

In this study, we demonstrated an essential function of the hexosamine biosynthesis pathway (HBP)-associated O-linked β-N-acetylglucosamine (O-GlcNAc) signaling in influenza A virus (IAV)-induced cytokine storm. O-GlcNAc transferase (OGT), a key enzyme for protein O-GlcNAcylation, mediated IAV-induced cytokine production. Upon investigating the mechanisms driving this event, we determined that IAV induced OGT to bind to interferon regulatory factor-5 (IRF5), leading to O-GlcNAcylation of IRF5 on serine-430. O-GlcNAcylation of IRF5 is required ...

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O-GLCNAC TRANSFERASE PROMOTES INFLUENZA A VIRUS-INDUCED CYTOKINE STORM BY TARGETING INTERFERON REGULATORY FACTOR-5

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