期刊论文

Study on Morphologic Features during DEN- induced Hepatocellular Carcinomas in Rats

中文

昆明医科大学学报

2095-610X

2005

03

15-19

云南省教育厅应用基础研究基金（04Z068C）；

本校为其他机构

目的:建立DEN肝癌模型并初步动态观察大鼠肝癌发生的病理形态演变过程.方法:用2‰DEN溶液灌喂诱发Wistar大鼠肝癌,病理常规HE染色动态观察.结果:病理学检查证实DEN成功诱发肝癌,诱癌率为87.17%（34/39）,大鼠肝癌癌变过程大致经过肝细胞损伤期、肝细胞增生硬化期和肝细胞癌变期等三个时期,具有与人体肝癌相似的病变过程及病理学变化特征.结论:该肝癌模型可作为研究人类肝癌的一种理想的动物模型.

Objective： To establish DEN - induced hepatocellular carcinomas model and investigate the morphologic evolution during hepatocarcinogenesis in rats. Methods： 2‰ DEN was administrate to Wistar rats, and a series histopathology re.search was employed to examine the hepatic lesions in diethylnitrosamine （DEN） -induced hepatocellular carcinomas model. Results： 87.17 % liver neoplasm was identified by mor- phologic investigation. The procession of hepatocarcinogenesis in this model included three stages - hepatic toxic lesion, hepatic prolifer...