On the basis of detrended fluctuation analysis (DFA), we propose a new bivariate linear regression model. This new model provides estimators of multi-scale regression coefficients to measure the dependence between variables and corresponding variables of interest with multi-scales. Numerical tests are performed to illustrate that the proposed DFA-bsaed regression estimators are capable of accurately depicting the dependence between the variables of interest and can be used to identify different dependence at different time scales. We apply this model to analyze the PM2.5 series of three adjace...