Molecular characterization and expression of TLR7 and TLR8 in barbel chub (Squaliobarbus curriculus): Responses to stimulation of grass carp reovirus and lipopolysaccharide

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成果类型：

期刊论文

作者：

Jin, Shengzhen;Zhao, Xin;Wang, Hongquan;Su, Jianming;Wang, Jing'an;...

通讯作者：

Li, Yaoguo;Xiao, Tiaoyi

作者机构：

[Wang, Hongquan; Xiao, Tiaoyi; Li, Yaoguo; Xiao, TY; Zhao, Xin; Ding, Chunhua; Jin, Shengzhen; Wang, Jing'an; Su, Jianming] Hunan Agr Univ, Hunan Engn Technol Res Ctr Featured Aquat Resourc, Changsha 410128, Hunan, Peoples R China.

[Wang, Hongquan; Xiao, Tiaoyi; Li, Yaoguo] Collaborat Innovat Ctr Efficient & Hlth Prod Fish, Changde 415000, Hunan, Peoples R China.

[Su, Jianming] Hunan Agr Univ, Coll Vet Med, Changsha 410128, Hunan, Peoples R China.

通讯机构：

[Li, YG; Xiao, TY] H

Hunan Agr Univ, Hunan Engn Technol Res Ctr Featured Aquat Resourc, Changsha 410128, Hunan, Peoples R China.

语种：

英文

关键词：

Squaliobarbus curriculus;cDNA cloning;Structure comparison;Expression change;Correlation analysis

期刊：

Fish & Shellfish Immunology

ISSN：

1050-4648

年：

2018

卷：

期：

页码：

292-307

DOI：

10.1016/j.fsi.2018.09.035

基金类别：

Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31572615, 31802288]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2017M612560, 2018T110833]

机构署名：

本校为第一且通讯机构

院系归属：

动物科学技术学院

动物医学院

摘要：

The barbel chub (Squaliobarbus curriculus) is a kind of small size commercial fish species that is widely spread in Asia and has shown significant resistance to disease. In this study, the full-length cDNA sequences of Toll-like receptor (TLR) 7 and 8 from S. curriculus, designated as ScTLR7 and ScTLR8, were cloned, and their differences in the structure and the responses to the grass carp (GCRV) infection and lipopolysaccharide stimulation were investigated. The full-length 3715 base pair (bp) cDNA of ScTLR7 contained a complete open reading frame of 3162 bp and encoded a putative polypeptide...

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Molecular characterization and expression of TLR7 and TLR8 in barbel chub (Squaliobarbus curriculus): Responses to stimulation of grass carp reovirus and lipopolysaccharide

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