Chitosan lowers body weight through intestinal microbiota and reduces IL-17 expression via mTOR signalling

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成果类型：

期刊论文

作者：

Xiao, Dingfu;Ren, Wenkai*;Bin, Peng;Chen, Shuai;Yin, Jie;...

通讯作者：

He, Jianhua;Ren, Wenkai

作者机构：

[Nan, Zi; Xiao, Dingfu; He, Jianhua] Hunan Agr Univ, Coll Anim Sci & Technol, Changsha 410128, Hunan, Peoples R China.

[Liu, Gang; Bin, Peng; Yin, Jie; Ren, Wenkai; Chen, Shuai; Gao, Wei; Xiao, Dingfu] Chinese Acad Sci, Inst Subtrop Agr, Key Lab Agroecol Proc Subtrop Reg,Sci Observing &, Hunan Prov Engn Res Ctr Hlth Livestock,Minist Agr, 644 Yuanda Rd, Changsha 410125, Hunan, Peoples R China.

[Xiao, Dingfu; He, Jianhua] Hunan Collaborat Innovat Ctr Utilizat Bot Funct I, Changsha 410128, Hunan, Peoples R China.

[Xiao, Dingfu; He, Jianhua] Hunan Collaborat Innovat Ctr Anim Prod Safety, Changsha 410128, Hunan, Peoples R China.

[Hu, Xionggui] Hunan Inst Anim & Vet Sci, Changsha 410131, Hunan, Peoples R China.

通讯机构：

[He, Jianhua] H

[Ren, Wenkai] C

Hunan Agr Univ, Coll Anim Sci & Technol, Changsha 410128, Hunan, Peoples R China.

Chinese Acad Sci, Inst Subtrop Agr, Key Lab Agroecol Proc Subtrop Reg,Sci Observing &, Hunan Prov Engn Res Ctr Hlth Livestock,Minist Agr, 644 Yuanda Rd, Changsha 410125, Hunan, Peoples R China.

语种：

英文

关键词：

Chitosan;IL-17;Intestinal microbiota;mTOR

期刊：

Journal of Functional Foods

ISSN：

1756-4646

年：

2016

卷：

页码：

166-176

DOI：

10.1016/j.jff.2016.01.009

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31301985]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2014M562111, 2015T80871]; Science and Technology Department of Hunan Province [2015RS4035]; College Students Innovation Project of Hunan Agricultural University [XCX14039]

机构署名：

本校为第一且通讯机构

院系归属：

动物科学技术学院

摘要：

This study was conducted to explore the effect of chitosan supplementation on mouse intestinal microbiota and interleukin-17 (IL-17) expression. Chitosan supplementation reduced mouse body weight, associating with change of intestinal microbiota (i.e. lowering the ratio of Firmicutes: Bacteroidetes). In antibiotics treated mice, chitosan supplementation had little effect on mouse body weight. Chitosan supplementation decreased expression of IL-17 in mouse jejunum and inhibited the mTOR pathway. In antibiotics treated mice, chitosan also reduced expression of IL-17 in the jejunum. Activation of...

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Chitosan lowers body weight through intestinal microbiota and reduces IL-17 expression via mTOR signalling

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