The effect of earthworm extract on mice S180 tumor growth and apoptosis

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成果类型：

期刊论文

作者：

Deng, Zhenhan;Gao, Shanshan;Xiao, Xiang;Yin, Ni;Ma, Shiyang;...

通讯作者：

Li, Yusheng

作者机构：

[Li, Yusheng; Deng, Zhenhan] Cent S Univ, Xiangya Hosp, Dept Orthopaed, Changsha 410008, Hunan, Peoples R China.

[Deng, Zhenhan] Shenzhen Univ, Dept Sports Med, Affiliated Hosp 1, Shenzhen Peoples Hosp 2, Shenzhen 518035, Guangdong, Peoples R China.

[Gao, Shanshan] Univ Colorado, Dept Cardiol, Anschutz Med Campus, Aurora, CO USA.

[Xiao, Xiang] Anim Hlth Inspect Inst Yuelu Dist, Changsha 410000, Hunan, Peoples R China.

[Yin, Ni; Ma, Shiyang] Cent S Univ, Xiangya Med Sch, 8 Year Program, Dept Clin Med, Changsha 410013, Hunan, Peoples R China.

通讯机构：

[Li, Yusheng] C

Cent S Univ, Xiangya Hosp, Dept Orthopaed, Changsha 410008, Hunan, Peoples R China.

Cent S Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha 410008, Hunan, Peoples R China.

语种：

英文

关键词：

Earthworm extract;Sarcoma;Tumor growth;Apoptosis;Bcl-2;Bax

期刊：

Biomedicine & Pharmacotherapy

ISSN：

0753-3322

年：

2019

卷：

115

页码：

108979

DOI：

10.1016/j.biopha.2019.108979

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81874030, 81402224]; Provincial Science Foundation of Hunan [2015JJ3139]; Health and Family Planning Commission of Hunan Province [B2016105]; Administration of Traditional Chinese Medicine of Hunan Province [2015116]; China Scholarship CouncilChina Scholarship Council [201606375101]

机构署名：

本校为其他机构

院系归属：

动物科学技术学院

摘要：

Great efforts have been made to explore the potential treatment for cancers, and the most common therapies include surgery, chemotherapy and radiotherapy. As an alternative medication, earthworms have drawn increased attention considering its abundance in resource, easy access and minor side effects compared to traditional therapies. However, few studies had focused on the antitumor effect of earthworm-derived components. The purpose of this study is to investigate whether earthworm extract has an effect on tumor cell apoptosis and growth. Earthworm extract (EE) was purified through multiple s...

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The effect of earthworm extract on mice S180 tumor growth and apoptosis

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