Modulatory Mechanisms of the NLRP3 Inflammasomes in Diabetes.

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成果类型：

期刊论文

作者：

Ding, Sujuan;Xu, Sheng;Ma, Yong;Liu, Gang*;Jang, Hongmei*;...

通讯作者：

Liu, Gang;Jang, Hongmei;Fang, Jun

作者机构：

[Liu, Gang; Ding, Sujuan; Ma, Yong; Jang, Hongmei; Fang, Jun; Liu, G] Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Hunan, Peoples R China.

[Xu, Sheng] Shandong Agr Univ, Coll Life Sci, Tai An 271018, Shandong, Peoples R China.

[Liu, Gang] Chinese Acad Sci, Hunan Prov Key Lab Anim Nutr Physiol & Metab Proc, Natl Engn Lab Pollut Control & Waste Utilizat Liv, CAS Key Lab Agroecol Proc Subtrop Reg,Inst Subtro, Changsha 410125, Hunan, Peoples R China.

通讯机构：

[Liu, G; Jang, HM; Fang, J] H

[Liu, Gang] C

Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Hunan, Peoples R China.

Chinese Acad Sci, Hunan Prov Key Lab Anim Nutr Physiol & Metab Proc, Natl Engn Lab Pollut Control & Waste Utilizat Liv, CAS Key Lab Agroecol Proc Subtrop Reg,Inst Subtro, Changsha 410125, Hunan, Peoples R China.

语种：

英文

关键词：

Glucose tolerance;NLRP3;diabetes;gut microbes;insulin resistance

期刊：

Biomolecules

ISSN：

2218-273X

年：

2019

卷：

期：

DOI：

10.3390/biom9120850

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China [31672457, 31772642]; Ministry of Agricultural of the People's Republic of China [2015-Z64, 2016-X47]; Hunan Provincial Science and Technology Department [2016NK2101, 2017NK2322, 2016WK2008, 2016TP2005]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2018M632963, 2019T120705]

机构署名：

本校为第一且通讯机构

院系归属：

生物科学技术学院

摘要：

The inflammasome is a multiprotein complex that acts to enhance inflammatory responses by promoting the production and secretion of key cytokines. The best-known inflammasome is the NLRP3 (nucleotide-binding oligomerization domain-like receptor [NLR] family pyrin domain-containing 3) inflammasome. The evidence has shown that the NLRP3 inflammasome, IL-1beta, thioredoxin-interacting protein (TXNIP), and pyroptosis play vital roles in the development of diabetes. This review summarizes the regulation of type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) by NLRP3 via modulation o...

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Modulatory Mechanisms of the NLRP3 Inflammasomes in Diabetes.

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