Acetylation at K108 of the NS1 protein is important for the replication and virulence of influenza virus

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Ma, Jingjiao;Wu, Rujuan;Xu, Guanlong;Cheng, Yuqiang;Wang, Zhaofei;...

通讯作者：

Sun, Jianhe;Li, Jinxiang

作者机构：

[Wang, Zhaofei; Ma, Jingjiao; Yan, Yaxian; Cheng, Yuqiang; Sun, Jianhe; Wang, Heng'an] Shanghai Jiao Tong Univ, Sch Agr & Biol, Shanghai Key Lab Vet Biotechnol, Key Lab Urban Agr South,Minist Agr, Shanghai 200240, Peoples R China.

[Li, Jinxiang] Chengdu Natl Agr Sci & Technol Ctr, Chengdu, Sichuan, Peoples R China.

[Xu, Guanlong] China Inst Vet Drug Control, Beijing 100081, Peoples R China.

[Wu, Rujuan] Hunan Agr Univ, Coll Vet Med, Changsha 410128, Peoples R China.

通讯机构：

[Sun, Jianhe] S

[Li, Jinxiang] C

Shanghai Jiao Tong Univ, Sch Agr & Biol, Shanghai Key Lab Vet Biotechnol, Key Lab Urban Agr South,Minist Agr, Shanghai 200240, Peoples R China.

Chengdu Natl Agr Sci & Technol Ctr, Chengdu, Sichuan, Peoples R China.

语种：

英文

期刊：

VETERINARY RESEARCH

ISSN：

0928-4249

年：

2020

卷：

期：

页码：

1-10

DOI：

10.1186/s13567-020-00747-3

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China [31702244]; Shanghai Science and Technology Foundation [18391902200]; National Key Research and Development Program of China [2018YFD0500100]; Shanghai Key Laboratory of Veterinary Biotechnology, Key Laboratory of Urban Agriculture [klab201607]

机构署名：

本校为其他机构

院系归属：

动物医学院

摘要：

Non-structural protein 1 (NS1) of influenza virus is a multifunctional protein that plays an important role in virus replication and virulence. In this study, an acetylation modification was identified at the K108 residue of the NS1 protein of H1N1 influenza virus. To further explore the function of the K108 acetylation modification of the NS1 protein, a deacetylation-mimic mutation (K108R) and a constant acetylation-mimic mutation (K108Q) were introduced into the NS1 protein in the background of A/WSN/1933 H1N1 (WSN), resulting in two mutant v...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Acetylation at K108 of the NS1 protein is important for the replication and virulence of influenza virus

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问