期刊论文

Effect of Yellow rice wine on intestinal microorganism in D-galactose induced aging mice based on high-throughput sequencing analysis

Hao, F.;Qin, S.

中文

食品与发酵工业

0253-990X

2020

46

2

32-39

10.13995/j.cnki.11-1802/ts.022229

本校为第一机构

该文用D-半乳糖(D-galactose,D-gal)颈脊皮下注射建立衰老小鼠模型,评价黄酒对衰老小鼠模型肠道菌群结构的影响。通过设立空白对照、模型组、黄酒组,6周后测定其抗氧化酶活力,同时采用Morris水迷宫对小鼠的认知能力进行测试。收集小鼠粪便,利用IonS5TMXL高通量测序平台对肠道细菌16S rDNA基因进行测序,探索黄酒摄入对衰老小鼠肠道微生物菌群的影响。结果表明,D-gal致衰老小鼠模型的抗氧化相关酶活性明显降低,丙二醛(malondialdehyde,MDA)水平显著增高(P

The objective of the study is to investigate the effects of Yellow rice wine ( YRW) on intestinal microbiota in .D-galactose (.D-gal) induced aging mice model. The aging model were established with .D-gal injection. Fifty Kunming mice were randomly and equally divided into control group, aging model group (model) , YRW group. After six weeks, the antioxidant enzyme activity and the content of malondialdehyde (MDA) in the liver and brain of mice were determined. Morris water maze (MWM) was used to test the learning and memory ability of mice in ...