Toxicity assessment of gelsenicine and the search for effective antidotes

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成果类型：

期刊论文

作者：

Li, Yu-Juan;Yang, Kun;Long, Xue-Ming;Xiao, Gang;Huang, Si-Juan;...

通讯作者：

Zhao-Ying Liu;Zhi-Liang Sun

作者机构：

[Zeng, Zi-Yue; Li, Yu-Juan; Huang, Si-Juan; Sun, Zhi-Liang; Xiao, Gang; Yang, Kun; Liu, Zhao-Ying] Hunan Agr Univ, Hunan Engn Technol Res Ctr Vet Drugs, Changsha, Peoples R China.

[Li, Yu-Juan] Xiangnan Univ, Dept Basic Med, Chenzhou, Peoples R China.

[Zeng, Zi-Yue; Li, Yu-Juan; Huang, Si-Juan; Sun, Zhi-Liang; Xiao, Gang; Yang, Kun; Liu, Zhao-Ying] Hunan Agr Univ, Coll Vet Med, Changsha, Peoples R China.

[Long, Xue-Ming] Hunan Prov Inst Vet Drugs & Feed Control, Changsha, Peoples R China.

[Sun, Zhi-Liang; Liu, Zhao-Ying] Hunan Agr Univ, Changsha 410128, Hunan, Peoples R China.

通讯机构：

[Zhao-Ying Liu; Zhi-Liang Sun] H

Hunan Agr Univ, Changsha 410128, Hunan, Peoples R China.

语种：

英文

关键词：

4 aminobutyric acid A receptor;alkaloid;antidote;diazepam;epinephrine;flumazenil;gelsenicine;unclassified drug;antidote;indole alkaloid;neurotoxin;plant extract;acute toxicity;animal experiment;animal model;animal tissue;Article;blood brain barrier;central nervous system;controlled study;death;female;gastrointestinal tract;Institute for Cancer Research mouse;LD50;male;mouse;nerve conduction;neurotoxicity;nonhuman;rat;respiratory failure;Sprague Dawley rat;survival rate;toxicity testing;animal;chemistry;comparative study;disease model;Gelsemium;human;mortality;respiratory failure;sex factor;Animals;Antidotes;Disease Models, Animal;Gelsemium;Humans;Indole Alkaloids;Male;Neurotoxins;Plant Extracts;Rats;Rats, Sprague-Dawley;Respiratory Insufficiency;Sex Factors

期刊：

Human & Experimental Toxicology

ISSN：

0960-3271

年：

2022

卷：

页码：

096032712110628

DOI：

10.1177/09603271211062857

基金类别：

The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was financially supported by the National Key Research and Development Programme of China (2017YFD0501403), The National Natural Science Foundation of China (31972737), and Doctoral Scientific Research Foundation of Henan University of Animal Husbandry and Economy (M4030068).

机构署名：

本校为第一且通讯机构

院系归属：

动物医学院

摘要：

Background: Gelsenicine, one of the most toxic alkaloids of Gelsemium elegans Benth (G. elegans), causes severe respiratory depression. However, its toxicity mechanisms are yet to be elucidated and no effective antidotes are available. Objective: This study aimed to analyse the toxicity characteristics of gelsenicine. Methods: Both acute and sub-acute toxicities were evaluated. Gelsenicine distribution and elimination in the central nervous system (CNS) and blood were observed. Effective antidotes for gelsenicine poisoning were screened. Result...

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Toxicity assessment of gelsenicine and the search for effective antidotes

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