期刊论文

Development of compound ciprofloxacin emulsion and its inhibitory effects in vitro

中文

中国兽医杂志

0529-6005

2011

47

10

79-80

10.3969/j.issn.0529-6005.2011.10.033

湖南省科技重点项目（2008NK2007） 长沙市科技重大专项（2009NK57）

本校为第一机构

为了充分发挥环丙沙星在兽医临床上的效果，克服其半衰期短和连续用药导致的不良反应，研制了一种复方环丙沙星乳剂。采用油乳剂灭活疫苗抗原缓释技术与药物乳剂制备技术相结合，将环丙沙星和乳酸TMP按5：1比例制备成一种油乳剂，并对其性状及稳定性进行研究。用复方环丙沙星注射液作为对照，进行了该乳剂对5种细菌的体外抑菌试验。结果表明：复方环丙沙星乳剂为淡黄色、油乳状，pH值为6．3～6．6，颗粒平均大小为7．6Fm，稳定性良好；复方环丙沙星乳剂对5种细菌的MIC值和MBC值显著强于复方环丙沙星注射液（P〈0．01）。

In order to investigate the efficiency of ciprofloxacin in clinical application and to overcome the shortcomings of the short half-life period that resulted in continuous medication, the long-acting prepa- ration of compound ciprofloxacin emulsion was successfully developed by combining the technology of the oil-emulsion inactivated vaccine antigen release with drug emulsion preparation. That is the oil emulsion was made by mixed the ciprofloxacin and trimethoprim lactic acid with the ratio of 5 ： 1. Besides, properties and stability were also...