The study was designed to establish a method for freeze -dried praziqnantel liposome agent preparation, as well as the corresponding quality control and assessment. The film - ultrasonic wave technique was initially used to prepare praziquantel liposomes, then freeze - drying technique used to yield the freeze - dried praziquantel liposome agent, the agent stability and the encapsulation efficiency were carefully assessed and determined via newly set up HPLC method. The encapsulation efficiency can be more than 70% with particle size range from 220 to 310 nm, most liposomes turned out to be ro...
