Short chain fatty acids(short-chain fatty acid, SCFA) usually refer to organic carboxylic acids with less than 6 carbon atoms. SCFAs in the intestine of monogastric animals are mainly produced by the decomposition of some carbon compounds which are difficult to digest in monogastric animals. Studies have shown that SCFAs plays a significant role in maintaining intestinal health, anti-inflammation and anticancer in monogastric animals. In this paper, the physiological functions and mechanisms of SCFAs in monogastric animals, such as improving intestinal epithelial barrier function, promoting in...