Treg expression of CIS suppresses allergic airway inflammation through antagonizing an autonomous TH2 program

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期刊论文

作者：

Zheng, Handong;Wu, Xiang;Wu, Dandan;Jiang, Ruo-Lan;Castillo, Eliseo F.;...

通讯作者：

Yang, Xuexian O.

作者机构：

[Zhou, Qin; Zheng, Handong; Jiang, Ruo-Lan; Yang, Xuexian O.; Wu, Xiang; Wu, Dandan; Chock, Cameron J.] Univ New Mexico, Dept Mol Genet & Microbiol, Sch Med, Albuquerque, NM 87131 USA.

[Jiang, Ruo-Lan; Wu, Xiang] Cent South Univ, Sch Basic Med Sci, Xiangya Sch Med, Dept Parasitol, Changsha, Peoples R China.

[Zhou, Qin; Liu, Meilian; Wu, Dandan] Univ New Mexico, Dept Biochem & Mol Biol, Sch Med, Albuquerque, NM 87131 USA.

[Wu, Dandan] Hunan Agr Univ, Coll Agron, Changsha 410128, Peoples R China.

[Castillo, Eliseo F.] Univ New Mexico, Dept Internal Med, Sch Med, Albuquerque, NM 87131 USA.

通讯机构：

[Yang, Xuexian O.] U

Univ New Mexico, Dept Mol Genet & Microbiol, Sch Med, Albuquerque, NM 87131 USA.

语种：

英文

期刊：

Mucosal Immunology

ISSN：

1933-0219

年：

2020

卷：

期：

页码：

293-302

DOI：

10.1038/s41385-019-0236-3

基金类别：

NCI NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Cancer Institute (NCI) [P30 CA118100]; NIAID NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Allergy & Infectious Diseases (NIAID) [R56 AI116772, R21 AI142200]; NIDDK NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) [R01 DK110439]; NIGMS NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of General Medical Sciences (NIGMS) [P20 GM121176]

机构署名：

本校为其他机构

院系归属：

农学院

摘要：

Maintenance of regulatory T (Treg) cells is crucial for the regulatory function of Treg cells in immune homeostasis and self-tolerance; however, the detailed underlying mechanisms remain elusive. In the current study, we found that the cytokine suppressor CIS (cytokine induced SH-2 protein) is required for maintenance of Treg cell identity. Mice with Treg-specific Cis-deficiency displayed aggravated experimental allergic asthma, and in adulthood, developed splenomegaly, lymphadenopathy and spontaneous eosinophilic airway inflammation, accompanied by accumulation of effector memory helper T (TH...

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Treg expression of CIS suppresses allergic airway inflammation through antagonizing an autonomous TH2 program

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