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Treatment with Subcritical Water-Hydrolyzed Citrus Pectin Ameliorated Cyclophosphamide-Induced Immunosuppression and Modulated Gut Microbiota Composition in ICR Mice

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成果类型:
期刊论文
作者:
Chen, Jianbing;Zhang, Chengcheng;Xia, Qile;Liu, Daqun;Tan, Xinghe*;...
通讯作者:
Tan, Xinghe
作者机构:
[Chen, Jianbing; Tan, Xinghe] Hunan Agr Univ, Coll Food Sci & Technol, Changsha 410128, Peoples R China.
[Liu, Daqun; Cao, Yan; Zhang, Chengcheng; Chen, Jianbing; Xia, Qile; Li, Yingdi] Zhejiang Acad Agr Sci, Minist Agr & Rural Affairs Food Sci Inst, Key Lab Post Harvest Handling Fruits, Inst Food Sci, Hangzhou 310021, Peoples R China.
通讯机构:
[Tan, Xinghe] H
Hunan Agr Univ, Coll Food Sci & Technol, Changsha 410128, Peoples R China.
语种:
英文
关键词:
Citrus pectin;Cyclophosphamide;Gut microbiota;Immunosuppression;Subcritical-water
期刊:
Molecules
ISSN:
1420-3049
年:
2020
卷:
25
期:
6
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [31501438]; Key Research and Development Project of Zhejiang Province [2018C02048]
机构署名:
本校为第一且通讯机构
院系归属:
食品科学技术学院
摘要:
Subcritical water can effectively hydrolyze pectin into smaller molecules while still maintaining its functional regions. Pectic heteropolysaccharide can mediate immune regulation; however, the possible effects of subcritical water-hydrolyzed citrus pectin (SCP) on the immune response remain unclear. Therefore, the effects of SCP on immunomodulatory functions and intestinal microbial dysbiosis were investigated using a cyclophosphamide-induced immunosuppressed mouse model. In this research, immunosuppressed ICR mice were administrated with SCP at dosages of 300/600/1200 mg/kg.bw by oral gavage...

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