MiR-135b-5p targets ADAM12 to suppress invasion and accelerate trophoblast apoptosis in preeclampsia

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成果类型：

期刊论文

作者：

Sun, Bo;Jiang, Taotao;Yong, Jiayao;Peng, Julan;Dong, Shangkun;...

通讯作者：

Chang, WL

作者机构：

[Sun, Bo] Shenzhen Baoan Womens & Childrens Hosp, Dept Obstet, Shenzhen 518101, Peoples R China.

[Sun, Bo; Jiang, Taotao; Luo, Liqiong] Second Peoples Hosp Shenzhen, Dept Obstet, Shenzhen 518035, Peoples R China.

[Chang, Wen-Lin; Gu, Yanli; Peng, Julan; Jiang, Taotao; Chang, WL; Luo, Liqiong; Dong, Shangkun] Southern Med Univ, Affiliated Longhua Peoples Hosp, Longhua Peoples Hosp, Dept Obstet, Shenzhen 518109, Peoples R China.

[Yong, Jiayao] Southern Med Univ, Dept Gynaecol & Obstet, Shenzhen Hosp, Shenzhen 510086, Peoples R China.

[Peng, Julan; Ji, Xinmei] Hunan Agr Univ, Coll Vet Med, Changsha 410128, Peoples R China.

通讯机构：

[Chang, WL ] S

Southern Med Univ, Affiliated Longhua Peoples Hosp, Longhua Peoples Hosp, Dept Obstet, Shenzhen 518109, Peoples R China.

语种：

英文

关键词：

ADAM12;Cell apoptosis;Cell invasion and migration;Preeclampsia;Trophoblast;miR-135b-5p

期刊：

Placenta

ISSN：

0143-4004

年：

2023

卷：

143

页码：

69-79

DOI：

10.1016/j.placenta.2023.10.004

基金类别：

This study was supported by Science and Technology Planning Project of Guangdong Province (2018A0303130277; 2021A1515010515), Shenzhen Science and Technology Innovation Program (JCYJ20180228163459314; JCYJ20190809090803702), and the Scientific Research Projects of Medical and Health Institutions of Longhua District, Shenzhen (2021022).

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本校为其他机构

院系归属：

动物医学院

摘要：

INTRODUCTION: Preeclampsia was a serious complication often leaded to adverse pregnancy outcomes. Abnormal placental miR-135b-5p expression in preeclampsia was observed in our preliminary investigation. However, the role of miR-135b-5p in preeclampsia was unclear. METHODS: We determined the miR-135b-5p expression pattern at the fetomaternal interface and levels in placental tissue and exosomes. MiR-135b-5p expression in the trophoblast cell line HTR8/SVneo was manipulated by transient agomir or antagomir transfection or establishment of HTR8/SVneo cell line stably overexpressing miR-135b or mi...

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MiR-135b-5p targets ADAM12 to suppress invasion and accelerate trophoblast apoptosis in preeclampsia

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