摘要：
A novel TiO2(B) confined in porous bio-derived carbon has been prepared for dehydrogenated catalyzation of NH3BH3. The microstructural characterizations of as-prepared samples show that the nanoconfinement in well-organized micro/mesopores of carbon can avoid the aggregations of TiO2(B) nanoparticles and NH3BH3. The dehydrogenation measurement demonstrates the dehydrogenated thermodynamic and dynamic properties of NH3BH3 could be improved under the con-catalyzation of TiO2(B) and porous carbon. The results suggest that both TiO2(B) and porous bio-derived C are promising catalysts. Additionally, it also provides a high-value solution for the disposal of agricultural wastes. (C) 2020 Hydrogen Energy Publications LLC. Published by Elsevier Ltd. All rights reserved.
摘要：
Mutations in the BSCL2 gene underlie human type 2 Berardinelli-Seip congenital lipodystrophy (BSCL2) disease. Global Bscl2(-/-) mice recapitulate human BSCL2 lipodystrophy and results in the development of insulin resistance and hypertrophic cardiomyopathy. The pathological mechanisms underlying the development of lipodystrophy and cardiomyopathy in BSCL2 are controversial. Here we report that Bscl2(-/-) mice develop cardiac hypertrophy because of increased basal IGF1 receptor-mediated (IGF1R-mediated) PI3K/AKT signaling. Bscl2(-/-) hearts exhibited increased adipose triglyceride lipase (ATGL) protein stability and expression causing drastic reduction of glycerolipids. Excessive fatty acid oxidation was overt in Bscl2(-/-) hearts, partially attributing to the hyperacetylation of cardiac mitochondrial proteins. Intriguingly, pharmacological inhibition or genetic inactivation of ATGL could rescue adipocyte differentiation and lipodystrophy in Bscl2(-/-) cells and mice. Restoring a small portion of fat mass by ATGL partial deletion in Bscl2(-/-) mice not only reversed the systemic insulin resistance, but also ameliorated cardiac protein hyperacetylation, normalized cardiac substrate metabolism, and improved contractile function. Collectively, our study uncovers pathways underlying lipodystrophy-induced cardiac hypertrophy and metabolic remodeling and pinpoints ATGL as a downstream target of BSCL2 in regulating the development of lipodystrophy and its associated cardiomyopathy.
期刊：
Communications in Computer and Information Science,2020年1156:476-482 ISSN：1865-0929
通讯作者：
Fan, H.
作者机构：
[Mi H.] PLA Strategic Support Force Information Engineering University, Zhengzhou, 450000, China;Henan Provincial Key Laboratory of Network Cryptography, Zhengzhou, 450000, China;[Qin L.] Hunan Agricultural University, Changsha, 410128, China;[Lu S.; Wang Y.; Fan H.] PLA Strategic Support Force Information Engineering University, Zhengzhou, 450000, China, Henan Provincial Key Laboratory of Network Cryptography, Zhengzhou, 450000, China
通讯机构：
[Fan, H.] P;PLA Strategic Support Force Information Engineering UniversityChina
会议名称：
1st International Conference on Blockchain and Trustworthy Systems, BlockSys 2019
