摘要：
Mutations in the BSCL2 gene underlie human type 2 Berardinelli-Seip congenital lipodystrophy (BSCL2) disease. Global Bscl2(-/-) mice recapitulate human BSCL2 lipodystrophy and results in the development of insulin resistance and hypertrophic cardiomyopathy. The pathological mechanisms underlying the development of lipodystrophy and cardiomyopathy in BSCL2 are controversial. Here we report that Bscl2(-/-) mice develop cardiac hypertrophy because of increased basal IGF1 receptor-mediated (IGF1R-mediated) PI3K/AKT signaling. Bscl2(-/-) hearts exhibited increased adipose triglyceride lipase (ATGL) protein stability and expression causing drastic reduction of glycerolipids. Excessive fatty acid oxidation was overt in Bscl2(-/-) hearts, partially attributing to the hyperacetylation of cardiac mitochondrial proteins. Intriguingly, pharmacological inhibition or genetic inactivation of ATGL could rescue adipocyte differentiation and lipodystrophy in Bscl2(-/-) cells and mice. Restoring a small portion of fat mass by ATGL partial deletion in Bscl2(-/-) mice not only reversed the systemic insulin resistance, but also ameliorated cardiac protein hyperacetylation, normalized cardiac substrate metabolism, and improved contractile function. Collectively, our study uncovers pathways underlying lipodystrophy-induced cardiac hypertrophy and metabolic remodeling and pinpoints ATGL as a downstream target of BSCL2 in regulating the development of lipodystrophy and its associated cardiomyopathy.
作者：
Liu Feng;Luo Jingyi;Wu Xuanyong;Wang Ningbo;Qin Sishi;...
作者机构：
Institute of Artificial Intelligence and Change Management, Shanghai University of International Business and Economics, Shanghai, China;Hunan Agricultural University, Changsha, Hunan, China;Ernst & Young LLP, Shanghai, China;Taihu College of Wuxi, Wuxi, Jiangsu, China;Changsha University of Science and Technology, Changsha, China
会议名称：
978-1-4503-7767-6
会议时间：
March, 2020
会议地点：
Hilo HI USA
会议论文集名称：
ICBCT'20: Proceedings of the 2020 The 2nd International Conference on Blockchain Technology
摘要：
In order to achieve the automatic and non-inductive reimbursement of invoices and eliminate the various inconveniences as well as risks caused by artificial reimbursement, this paper creatively combines blockchain technology with electronic invoices. This system realizes interactive flows of paperless invoice for each node from consumption, reimbursement to tax payment through the blockchain network system. Based on the Internet of things technology, the off-chain data can be automatically processed and connected to the on-chain seamlessly. Meanwhile, using a dual-chain structure ensures the subsequent identification and business separation. Through the combination of theory and technical framework, the non-inductive invoice reimbursement system is constructed to reduce the overall reimbursement costs and promoting the improvement of the taxation system in China.
