作者：
FAN Zhiyong;ZHANG Guanglei;ZHOU Dinggang;LIANG Zhe;WU Xin;...
期刊：
Biochemistry & Pharmacology: Open Access,2015年4(5):1-5
作者机构：
[FAN Zhiyong; ZHANG Guanglei] Engineering Research Center for Feed Safety and Efficient Utilization of Ministry of Education,Institute of Animal Nutrition, Hunan Agricultural University, Hunan 410128, China;[WANG Fenglai] State Key Laboratory of Animal Nutrition, Beijing 100081, China;[ZHOU Dinggang; LIANG Zhe] College of Animal Science and Technology,Sichuan Agricultural University, Yaan 625014, China;[WU Xin] Hunan Provincial Engineering Research Center of Healthy Livestock, Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, Hunan 410125, China;[FAN Zhiyong] State Key Laboratory of Animal Nutrition, Beijing 100081, China
会议名称：
中国畜牧兽医学会动物营养分会第七届中国猪营养学术研讨会
会议时间：
2015-10-1
会议地点：
重庆
会议主办单位：
中国畜牧兽医学会
会议论文集名称：
中国畜牧兽医学会动物营养分会第七届中国猪营养学术研讨会论文集
关键词：
Fan Zhiyong;Zhang Guanglei;Zhou Dinggang;Liang Zhe;Wu Xin and Wang Fenglai;Peptide tyrosine;Tyrosine;Antiserum;Digestive enzymes;Rat
摘要：
The object of this study was to investigate the effect of serum antibody of peptide tyrosine tyrosine on activities of digestive enzymes in rats. A total of sixty sprague-dawley (SD) rats weighing 87.77 ± 1.61 g were randomly allocated to 1 of 4 dose treatment:0 (control), 50 μL, 100 μL, or 200 μL peptide tyrosine tyrosine antiserum during the 21-d experimental period. The activity of amylases and lipases in the pancreas and duodenum as well as gastric pepsin was measured at the end of the study. The results showed that the activity of lipases in the pancreas and duodenum increased with increasing peptide tyrosine tyrosine antiserum level, but obvious tendency of pancreatic lipases activity between all treatments was not observed(P>0.05). The lipase activity in the duodenum showed a significant increase (P<0.05) in the groups treated with 100 μL or 200 μL of peptide tyrosine tyrosine antiserum compared with the control group. The amylase activity in the pancreas and duodenum increased with the increasing peptide tyrosine tyrosine antiserum dose, and the group treated with 200 μL of peptide tyrosine tyrosine antiserum was significantly higher (P<0.05) than the other groups. The amylase activity in the duodenum showed no significant difference (P>0.05) among groups, but the group treated with 200 μL of PYY antiserum showed the highest activity. In conclusion, the injection of peptide tyrosine tyrosine antiserum improved nutrition utilization rate and activity of digestive enzymes in a dose dependent manner in rats.
期刊：
Advance Journal of Food Science and Technology,2013年5(2):99-105 ISSN：2042-4868
通讯作者：
Fan, Z.-Y.
作者机构：
[Zhi-Yong Fan; Ding-Gang Zhou] Department of Animal Science and Technology, Hunan Agricultural University, Changsha, 410128, China;[Zhi-Yong Fan; Ping Zhou] Department of Foreign Language, Hunan Agricultural University, Changsha, 410128, China;[Zhi-Yong Fan; Guo-Hua Liu] Key Laboratory of Feed Biotechnology, Ministry of Agriculture of the People's Republic of China, Beijing, 100081, China;[Zhi-Yong Fan; Zhong-Hua Liu] Research Center of Engineering Technology for Utilization of Functional Ingredients from Botanicals, Hunan Agricultural University, Changsha, 410128, China;[Zhi-Yong Fan; Xiao-Song Wu] Engineering Research Center for Feed Safety and Efficient Utilization, Ministry of Education, Hunan Agricultural University, Changsha, 410128, China
通讯机构：
[Fan, Z.-Y.] D;Department of Animal Science and Technology, Hunan Agricultural University, China
摘要：
GABAAα1 and GABAB1 receptor subunits are responsible for most behavioral, physiological and pharmacological effects of GABA receptors. We investigated the expression of GABAAα1 and GABAB1 receptor subunits in different tissues of gilts during late pregnancy in hot summer. The mRNA abundance of GABAAα1 receptor subunit in different tissues of gilts at d 90 and d 110 of gestation was as follows: d 90: brain > lung > liver > ovary > spleen > kidney > heart; d 110: brain > lung > spleen > liver > ovary > kidney > heart. And, the mRNA abundance of GABAB1 receptor subunit was as follows: d 90: spleen > lung > brain > kidney > ovary > liver > heart; d 110: spleen > lung > kidney > brain > ovary > liver > heart. The results in this trial indicated that the GABAAα1 receptor subunit was abundantly expressed in brain, while GABAB1 receptor subunit was abundant in spleen and lung of gilts during late gestation. There were no gestation stage-dependent effects on GABAAα1 and GABAB1 receptor subunits expression in all tissues.
期刊：
The Journal of Nutrition,2012年142(6):990-998 ISSN：0022-3166
通讯作者：
Feng, Cuiping
作者机构：
[Li, Zhen; Wang, Junjun; Lin, Gang; Dai, Zhaolai; Lai, Changhua; Wu, Guoyao; Liu, Chuang] China Agr Univ, State Key Lab Anim Nutr, Beijing 100094, Peoples R China.;[Feng, Cuiping] China Japan Friendship Hosp, Dept Obstet & Gynecol, Beijing, Peoples R China.;[Li, Zhen] China Agr Univ, State Key Lab Plant Physiol & Biochem, Beijing 100094, Peoples R China.;[Fan, Zhiyong] Hunan Agr Univ, Coll Anim Sci & Technol, Changsha, Hunan, Peoples R China.;[Wu, Guoyao] Texas A&M Univ, Dept Anim Sci, College Stn, TX 77843 USA.
通讯机构：
[Feng, Cuiping] C;China Japan Friendship Hosp, Dept Obstet & Gynecol, Beijing, Peoples R China.
摘要：
Intrauterine growth restriction (IUGR) remains a major problem for both human health and animal production due to its association with high rates of neonatal morbidity and mortality, low efficiency of food utilization, permanent adverse effects on postnatal growth and development, and long-term health and productivity of the offspring. However, the underlying mechanisms for IUGR are largely unknown. In this study, one IUGR fetus and one normal body weight (NBW) fetus were obtained from each of 9 gilts at each of 2 gestational ages (d 90 and 110). Metabolomes of umbilical vein plasma in IUGR and NBW fetuses were determined by MS, while hormones, amino acids, and related metabolites in maternal and fetal plasma were measured using assay kits and chromatographic methods. Metabolites (including glucose, urea, ammonia, amino acids, and lipids) in umbilical vein plasma exhibited a cluster of differences between IUGR and NBW fetuses on d 90 and 110 of gestation. These changes in the IUGR group are associated with disorders of nutrient and energy metabolism as well as endocrine imbalances, which may contribute to the retardation of fetal growth and development. The findings help provide information regarding potential mechanisms responsible for IUGR in swine and also have important implications for the design of effective strategies to prevent, diagnose, and treat IUGR in other mammalian species, including humans.
