期刊：
NEW JOURNAL OF CHEMISTRY,2019年43(15):6010-6020 ISSN：1144-0546
通讯作者：
Zhou, Wen;Zhou, Li
作者机构：
[Fu, Kaishuo; Yuan, Sisi; Zhou, Wen; Huang, Weiping; Li, MaoLin] Guangzhou Univ Chinese Med, Sch Pharmaceut Sci, Waihuan Rd, Guangzhou 510006, Guangdong, Peoples R China.;[Jiang, Zhilin] Puer Univ, Puer, Yunan, Peoples R China.;[Shi, Yonghui] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Pharm, Guangzhou 510120, Guangdong, Peoples R China.;[Chen, YongJun] Guangzhou Univ Chinese Med, South China Res Ctr Acupuncture & Moxibust, Med Coll Acu Moxi & Rehabil, Waihuan Rd, Guangzhou 510006, Guangdong, Peoples R China.;[Zhou, Li] Hunan Agr Univ, Coll Sci, Changsha 410128, Hunan, Peoples R China.
通讯机构：
[Zhou, Wen] G;[Zhou, Li] H;Guangzhou Univ Chinese Med, Sch Pharmaceut Sci, Waihuan Rd, Guangzhou 510006, Guangdong, Peoples R China.;Hunan Agr Univ, Coll Sci, Changsha 410128, Hunan, Peoples R China.
摘要：
The tumor-seeking role of bleomycin (BLM) disaccharide has been demonstrated to serve as a promising tool for cancer diagnosis and a potential ligand for targeted therapy. However, these practical applications are often hampered by the lack of BLM disaccharide. Herein, an efficient multi-gram synthesis of peracetylated BLM disaccharide 20 is achieved by a TMSOTF-mediated glycosidation coupling manner in 43.6% overall yield in terms of benzyl galactoside. The critical innovation of the synthetic strategy is that inexpensive benzyl galactoside was first adopted to prepare an l-gulose subunit 3 as a glycosyl acceptor, with a much shorter route in 73.0% yield, and a 3-O-carbamoyl-mannose donor 4 was achieved in 47.2% yield by lowering the amount of dibutyltin oxide, and merging aminolysis and selective deacetylation into a one-pot reaction. Next, the incorporation of BLM disaccharide into 10-hydroxycamptothecin (10-HCPT), a non-specific model compound, to form conjugate 1 could significantly improve the antitumor activity and display obvious selectivity toward cancerous and normal cells in comparison with 10-HCPT. Moreover, BLM disaccharide itself was non-cytotoxic, clearly indicating the importance and potential of BLM disaccharide in solving the targeted antitumor therapy of cytotoxic drugs.
作者机构：
[Zhuang, Shuxin; Peng, Zhengyu; Lu, Mi; Zhou, Litao; Lin, Daqin; Zhuang, SX] Xiamen Univ Technol, Sch Mat Sci & Engn, Key Lab Funct Mat & Applicat Fujian Prov, Xiamen 361024, Peoples R China.;[Zhou, Nan] Hunan Agr Univ, Coll Sci, Changsha 410128, Hunan, Peoples R China.;[Wu, Qihui] Quanzhou Normal Univ, Sch Chem Engn & Mat Sci, Dept Chem Mat, Quanzhou 362000, Peoples R China.
通讯机构：
[Zhuang, SX; Lu, M] X;Xiamen Univ Technol, Sch Mat Sci & Engn, Key Lab Funct Mat & Applicat Fujian Prov, Xiamen 361024, Peoples R China.
关键词：
Dye-sensitized solar cells;Hydrothermal method;Cu modification;Zinc oxide
摘要：
The Cu-modified ZnO nanoflowers as photoanode material for dye sensitized solar cells are synthesized via a cetylmethylammonium bromide-assisted hydrothermal method. The main phase of the synthesized samples well matches the wurtzite type phase of ZnO. And the pure phase of Cu begins to appear and strengthen when the modified-Cu content excesses 1 wt%, indicating that Cu element not only dope into the lattice of ZnO but also cover on its surfaces. It is found that the morphologies of the ZnO samples can be tuned by the change of the modified-Cu content, from irregular nanoplates to cross-linked multi-leveled porous nanoflowers with a various Cu concentration of 0.5 wt%, 1 wt%, 1.5 wt% and 2 wt%, which further facilitate the dye adsorption and light-scattering. The photocurrent-voltage characteristics and electrochemical impedance spectroscopy are conducted to estimate the electrochemical properties of these solar cells with different Cu modification contents. Compared to the dye-sensitized solar cells with pure ZnO electrode, all the dye-sensitized solar cells with Cu-modified ZnO photoelectrodes present higher photovoltaic performance. The introduction of Cu into ZnO significantly enhances electron transport and retards charge recombination in the ZnO-dye interfaces, which induce the 84% improvement of short-circuit current density and 1.6 times enhancement of the power conversion efficiency for the dye-sensitized solar cells with 1.5 wt% Cu-modified ZnO photoelectrodes. (c) 2018 Elsevier Ltd. All rights reserved.
期刊：
ACS Energy Letters,2018年3(9):2159-2166 ISSN：2380-8195
通讯作者：
Prezhdo, Oleg, V;Akimov, Alexey, V
作者机构：
[Li, Wei] Hunan Agr Univ, Coll Sci, Changsha 410128, Hunan, Peoples R China.;[Zhou, Liujiang] Los Alamos Natl Lab, Los Alamos, NM 87545 USA.;[Prezhdo, Oleg, V] Univ Southern Calif, Dept Chem, Los Angeles, CA 90089 USA.;[Akimov, Alexey, V] Univ Buffalo State Univ New York, Dept Chem, Buffalo, NY 14260 USA.
通讯机构：
[Prezhdo, Oleg, V; Akimov, Alexey, V] U;Univ Southern Calif, Dept Chem, Los Angeles, CA 90089 USA.;Univ Buffalo State Univ New York, Dept Chem, Buffalo, NY 14260 USA.
摘要：
Carbohydrates and their conjugates play important roles in many biological processes including fertilization, differentiation, development, immune response, and infection. Their activities are largely dependent on the properties of terminal mono- or disaccharides. Galactose, mannose, fucose, glucose, sialic acid, etc., are commonly used as powerful scaffolds installed on drug molecules for targeting specific tissues including brain, liver, and cancers, and as epitopes for enhancing the targeting of various vaccines. This review focuses on the influence of their structural variations, including changes in sugar type, substituent groups and their positions, as well as length of linker portion, on the targeting of drugs or their efficacy. Particular attention is paid to the targeting properties of mono- and disaccharides applied in drug design and discovery.
摘要：
The problem of land is the focus of China’s reform.Under the background of vigorously promoting rural land reform,it is necessary to explore the influencing factors of rural farmland circulation and provide reference for the government toformulate policies and thus increase the income of farmers.In this paper,six representative indexes and multiple regression wasused to analyze farmland circulation.The results show that the GDP per capita,the proportion of migrant labor,the agriculturalsubsidy,the average area of contracted land for each household and the number of employees in township enterprises are impor原tant to the development of the agricultural land circulation in China
摘要：
We introduce an MV-topology on the set of all valuations of MV-algebra and then establish Lukasiewicz semantic MV-topological space. We study the topological properties of Lukasiewicz semantic MV-topology, and prove that the Lukasiewicz semantic MV-topological space is a compact zero dimension Hausdorff MV-topological space and a N-compact space. We also establish a classical topology D on the valuations set of MV-algebra, and prove that topology D is finer than the cut topology C generated by Lukasiewicz semantic MV-topology. We prove that a s-complete lattice is an MV-algebra if and only if it is isomorphic to an MV-clopen lattice of a Stone MV-space. As an application, we use the compactness of topology D to prove the compactness of Lukasiewicz semantic and Lukasiewicz propositional logic system.
会议论文集名称：
DEStech Transactions on Environment Energy and Earth Sciences
摘要：
As cities develop in a fast pace, smart growth has become the goals for the city development of each country. In this paper, we take Atlanta as an example, then we build index assessment system of smart growth, which focus on economic prospection, social equity and environment sustainability (three of "E"). We choose ten typical indexes to measure three of "E" and use all-arranged polygon graphic index method to build smart growth mode. We build linear fitting functions for ten typical indexes respectively with the origin data in Atlanta from 2006 to 2014, then we get the predictable data in 2015 through the linear fitting functions. The next step is to bring this data to the mode and compute comprehensive scores with the year ranging from 2006 to 2015; besides, we compare the score in 2015 with that calculated by actual data. Then we do a significant test for them and the result indicates that the two scores are consistent. Smart growth mode we have built is effective, so we can use it to do prediction for the urban smart growth in the future.
