摘要：
脱氧雪腐镰刀菌烯醇(deoxynivalenol,DON)是谷物及谷物产品中最常见的一种真菌毒素,其主要通过激活丝裂原活化蛋白激酶(mitogen-activated protein kinases,MAPKs)等细胞信号转导通路以及线粒体介导细胞凋亡途径而发挥免疫毒性作用——抑制蛋白质合成、诱导细胞凋亡、损伤肠道和抑制机体免疫等,对人和动物的健康造成了巨大的影响。综述了DON对机体肠道的组织形态、屏障功能的损伤,及其对肠道相关细胞、黏膜免疫球蛋白的分泌、细胞因子的表达和肠道微生物平衡的影响,并进一步阐述了其作用机理,以期为DON的研究提供参考。
摘要：
Malignant tumor which can proliferate abnormally and transfer rapidly to other tissues, holds high mortality rate and is difficult to cure. Herewith it is responsible for great loss in economy. L-theanine, the specific amino acid in tea, performed a significant anti-tumor potential, it works via various methods, such as exert antitumor effect by itself; increase antitumor drugs concentration in tumor cells, inhibit tumor cell invasion and so on. Here, the authors elucidate and discuss these mechanisms comprehensively.
期刊：
Journal of Food, Agriculture and Environment,2013年11(3-4):151-154 ISSN：1459-0255
作者机构：
Chinese Acad. Sci., Inst. Subtrop. Agr., Res. Ctr Healthy Breeding Livestock and Poultry, Hunan Engn and Res. Ctr Anim. and Poultry Sci., Key Lab Agroecol. Proc. Subtrop. Reg, Furong Road #644, Changsha City, Hunan 410125, China;Department of Animal Science, Texas A and M University, College Station, TX 77843, United States;Department of Agricultural Leadership, Education and Communications, Texas A and M University, College Station, TX 77843, United States;College of Animal Science and Technology, Hunan Agricultural University, Nongda Road #1, Changsha City, Hunan 410128, China
关键词：
Fat;Muscle;mTOR signaling;α-ketoglutarate
摘要：
Obesity is a major public health crisis worldwide. This study was conducted to test the beneficial effect of α-ketoglutarate (α-KG) in obesity objects. Male Sprague-Dawley rats were fed for 15 wk a high-fat (40% energy) diet beginning at 4 wk of age, resulting in 30% higher body weight gains higher weights in HF than normal fed rats. Starting at 19 wk of age, the rats continued to be fed their diets and receive drinking water containing 0 or 1% α-KG (n = 8 per group) for 10 weeks. Water consumption was measured daily. Food intake and body weights were recorded weekly. At the end of trial, venous blood samples from tail were obtained for metabolite analysis, whereas gastrocnemius muscles were weighed and collected to determine the abundance and phosphorylation state of the mammalian target of the rapamycin (mTOR), ribosomal protein S6 kinase 1 (S6K1) and eukaryotic initiation factor (eIF) 4E-binding protein-1 (4E-BP1). In addition, retroperitoneal (RP), epididymal (EP), subcutaneous (SC; inguinal), and mesenteric (MT) fat tissues, as well as brown adipose tissue (located in the interscapular region), brain, kidney, and other tissues were dissected and weighed. The data indicated that 1% α-KG supplementation had no effect on adipose tissue, but increased (P<0.05) gastrocnemius muscle weight compared to control group. Consistent with these data, the addition of 1% α-KG increased (P<0.05) the phosphorylated levels of mTOR and 4E-BP1 proteins. Interestingly, in present study the data showed that α-KG supplementation decreased (P<0.05) the leucine level in plasma. Collectively, our finding may provide new clues for nutritional or pharmacological strategies to treat obese subjects.
期刊：
Advance Journal of Food Science and Technology,2013年5(2):99-105 ISSN：2042-4868
通讯作者：
Fan, Z.-Y.
作者机构：
[Zhi-Yong Fan; Ding-Gang Zhou] Department of Animal Science and Technology, Hunan Agricultural University, Changsha, 410128, China;[Zhi-Yong Fan; Ping Zhou] Department of Foreign Language, Hunan Agricultural University, Changsha, 410128, China;[Zhi-Yong Fan; Guo-Hua Liu] Key Laboratory of Feed Biotechnology, Ministry of Agriculture of the People's Republic of China, Beijing, 100081, China;[Zhi-Yong Fan; Zhong-Hua Liu] Research Center of Engineering Technology for Utilization of Functional Ingredients from Botanicals, Hunan Agricultural University, Changsha, 410128, China;[Zhi-Yong Fan; Xiao-Song Wu] Engineering Research Center for Feed Safety and Efficient Utilization, Ministry of Education, Hunan Agricultural University, Changsha, 410128, China
通讯机构：
[Fan, Z.-Y.] D;Department of Animal Science and Technology, Hunan Agricultural University, China
作者机构：
[易翠平; 钟春梅; 何英和] School of Chemistry and Biological Engineering,Changsha University of Science and Technology;[向建国] College of Animal Science and Technology,Hunan Agriculture University;[赵思明] College of Food Science and Technology,Huazhong Agricultural Univers
