摘要：
BACKGROUND: Recent works suggest recent changes in anhedonia may be specifically predictive of key elements of psychopathology. The present study aimed to identify the trajectories of state anhedonia and recent changes in anhedonia, and to investigate their associations with other psychiatric syndromes over time. METHODS: A total of 859 college students were assessed at three time points. State anhedonia was assessed using the Snaith Hamilton Pleasure Scale and recent changes in anhedonia were assessed with a subscale extracted from the Symptom Check-List-90. The Latent Growth Curve Modelling analysis was used to analyze trajectories. Associations with anhedonia were investigated with logistic regression models. RESULTS: Three state anhedonia trajectories and two recent changes in anhedonia trajectories were identified. The decreasing trajectory was the most prevalent class in both two types of anhedonia. Depression and suicidal ideation predicted recent changes in anhedonia whereas other psychiatric syndromes predicted state anhedonia. CONCLUSIONS: The current study highlighted the development trajectories of different measures of anhedonia. The results showed that the relationships between anhedonia and psychiatric syndromes were different according to the kind of anhedonia.
摘要：
Background: Obsessive-compulsive personality disorder (OCPD) is one of the most prevalent personality disorders in general population. However, neural mechanisms underlying OCPD remain elusive. The aim of this study is to use functional magnetic resonance imaging (fMRI) to examine whether OCPD patients will exhibit altered spontaneous brain activity as compared to healthy controls (HC). Methods: Resting-state fMRI data were acquired in 37 OCPD patients and 37 matched HC. Amplitudes of low-frequency fluctuation (ALIT) were calculated and compared between the two groups. Correlation analysis was performed between regional ALFF values and OCPD severity scores. Results: Significant group differences in regional ALFF were found in multiple brain regions. Compared to HCs, OCPD subjects had increased ALFF in bilateral caudate, left precuneus, left insula, and left medial superior frontal gyrus, and decreased ALFF in the right fusiform gyrus and left lingual gyrus. The ALFF values in the left precuneus correlated with OCPD severity scores. Limitations: We excluded patients with comorbidity and did not conduct cognitive function assessments. Our findings are also limited to cross-sectional analysis. Conclusions: OCPD patients exhibit altered spontaneous neural activity as compared to healthy controls in multiple brain regions, which may reflect different characteristic symptoms of OCPD pathophysiology, including cognitive inflexibility, excessive self-control, lower empathy, and visual attention bias. (C) 2019 University of Cape Town. Published by Elsevier B.V.
摘要：
BACKGROUND: Recent works suggested taking into account the severity and the type of anhedonia when examining suicidal ideation. The present study investigated a moderated mediation model addressing the psychosocial mechanisms that account for the association between state or trait anhedonia and suicidal ideation. METHODS: State anhedonia was assessed using the Snaith-Hamilton Pleasure Scale, while trait anhedonia was assessed using the Temporal Experience of Pleasure Scale. A total number of 1,361 of undergraduates completed questionnaires at three different times, with one-year intervals. RESULTS: The direct effect of stress on suicidal ideation was significantly greater for those students who had lower trait anticipatory and consummatory anhedonia, whereas the indirect effect from stress on suicidal ideation through depression was significantly greater for those who had higher state anhedonia. Moreover, trait consummatory anhedonia moderated the relationship between stress and suicidal ideation after one year, and trait anticipatory anhedonia moderated the relationship between stress and suicidal ideation after two years. CONCLUSIONS: Low levels of trait anhedonia were associated with elevated suicidal ideation, while high levels of state anhedonia were associated with elevated suicidal ideation. Trait consummatory anhedonia was associated with short-term suicidal ideation, while trait anticipatory anhedonia was associated with long-term suicidal ideation.
摘要：
OBJECTIVE: To study the developmental trajectory of hope among late-adolescents, taking population heterogeneity and the impact of gender and family socioeconomic status (SES) into consideration. METHODS: The study used the Snyder Hope Scale to perform four surveys of a sample of 381 Chinese late-adolescents, both male and female, with a mean age of 17.69+/-1.12 years, over the course of one year, and employed a growth mixture model to perform data analysis. RESULTS: Although the levels of hope among the respondents who had high and moderate levels of hope at the outset of the study remained relatively stable over the course of the year, those with low levels of hope exhibited a significant decrease over time. CONCLUSIONS: There is significant population heterogeneity in late-adolescents' developmental trajectory of hope. Additionally, gender and family SES have a significant effect on the developmental trajectory of hope, as significantly more female students than male students reported high levels of hope. Furthermore, participants with high family SES outnumbered those with low family SES in the high-hope group, whereas those with low SES outnumbered those with high SES in the low-hope group.
摘要：
This study was conducted to explore the unclear relationships among stress and self-esteem and life satisfaction of perfectionists. A sample of 1957 Chinese undergraduates completed Frost Multidimensional Perfectionism Scale (FMPS), Perceived Stress Scale (PSS), Rosenberg Self-Esteem Scale (RSES), and Quality of Life Enjoyment and Satisfaction Questionnaire-short form (Q-LES-Q). Cluster analysis was used to define categories of perfectionists and nonperfectionists. Correlation analysis and structural equation modeling were also used. Results showed that adaptive perfectionists had higher RSES scores and Q-LES-Q scores and lower PSS scores than maladaptive perfectionists (all p < 0.01). All variables were correlated significantly (all p < 0.01) and were included in the final structural equation model, which fitted the data well. These results indicated that both stress and self-esteem mediated the relationships between adaptive and maladaptive perfectionism and life satisfaction, and self-esteem suppressed the negative effect of stress on life satisfaction.
摘要：
Anhedonia is associated with dysfunction of the neural circuitry of reward in patients with major depressive disorder (MDD). However, its neurobiological basis is not fully understood. The present study examined the association between anhedonia and white matter (WM) characteristics in patients with first-episode MDD. We recruited 30 patients with first-episode drug-naive MDD and 28 healthy controls (HC) to undergo diffusion weighted imaging. We examined specifically the correlation between WM characteristics and anhedonia measured with the Temporal Experience of Pleasure Scale (TEPS) in MDD patients. Using Track-Based Spatial Statistics (TBSS), we found that MDD patients exhibited reduced fractional anisotropy (FA) in the left cingulum and the forceps minor. These patients also exhibited increased radial diffusivity (RD) in several major tracts including the bilateral anterior thalamic radiation, the corticospinal tract, the superior longitudinal fasciculus and the uncinate fasciculus in the left hemisphere. Correlational analysis showed that increased RD was significantly correlated with anticipatory anhedonia in the MDD group, while reduced mean FA was correlated with consummatory anhedonia in HC. These preliminary findings suggest that left-sided WM tracts abnormalities may contribute to the development of anhedonia in MDD patients.
摘要：
The aim of the current study was to examine the association between age at symptom onset and action cancelation in adults with obsessive-compulsive disorder (OCD). Performance on the stop-signal task was compared among adult patients with early-onset OCD (n = 63, onset age ≤ 19), late-onset OCD (n = 33, onset age ≥ 20), and healthy controls (n = 51). Stop-signal reaction time (SSRT) was significantly longer in both OCD groups compared to the control group. However, no significant differences were found between the two OCD groups. In addition, age at symptom onset was not associated with response inhibition performance in adults with OCD. The study findings support the existence of reduced performance on action cancelation in patients with OCD compared to healthy controls with no difference between early- and late-onset OCD subtypes.
关键词：
*Default mode network;*Melancholic major depressive disorder;*Network homogeneity;*Resting-state imaging
摘要：
Background: Melancholic depression is a relatively homogenous subtype of major depressive disorders (MDD). The condition has several endogenous symptoms and represents strong biological components. However, its specific neurobiological mechanisms remain unknown. Previous neuroimaging findings indicated that default mode network (DMN) is closely related to MDD. The present study examined the network homogeneity (NH) of the DMN in patients with melancholic MDD. Methods: A total of 33 first-episode, treatment-naive melancholic MDD patients and 32 healthy controls underwent a resting-state functional magnetic resonance imaging scan. The data were analyzed using the NH method. Results: Compared with healthy controls, patients with melancholic MDD showed low NH values in the right middle temporal gyrus and temporal pole (MTG/FP). The abnormal NH of this region and clinical characteristics were not correlated. Conclusion: Abnormal NH pattern of DMN exists in patients with melancholic MDD. This feature may be part of the pathophysiological basis of this disorder. (C) 2016 Elsevier B.V. All rights reserved.
作者机构：
[Fan, Jie; Zhu, Xiongzhao; Liu, Wanting; Gan, Jun; Niu, Chaoyang] Cent S Univ, Xiangya Hosp 2, Med Psychol Ctr, Renmin Rd 139, Changsha 410011, Hunan, Peoples R China.;[Lei, Hui] Hunan Agr Univ, Coll Educ, Changsha 410128, Hunan, Peoples R China.;[Chan, Raymond C. K.] Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing, Peoples R China.;[Chan, Raymond C. K.] Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China.
通讯机构：
[Zhu, Xiongzhao] C;Cent S Univ, Xiangya Hosp 2, Med Psychol Ctr, Renmin Rd 139, Changsha 410011, Hunan, Peoples R China.
关键词：
*Executive function;*Mentalizing;*Obsessive-compulsive disorder;*Social cognition;*Theory of mind
摘要：
Impairment in social functioning has been widely described in obsessive-compulsive disorder (OCD). However, several aspects of social cognition, such as theory of mind (ToM), have not been substantially investigated in this context. This study examined cognitive and affective ToM in 40 OCD patients and 38 age-, sex-, and education-matched healthy controls (HCs) with the computerized Yoni task and a battery of neurocognitive tests. OCD symptom severity was assessed with the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS). Depressive and anxiety symptoms were also assessed. Compared to HCs, OCD patients performed worse on second-order affective condition trials, but not cognitive or physical condition trials, of the Yoni task; there were not group differences in any of the first-order condition domains. Second-order ToM performance of OCD patients was associated with estimated intelligence and working memory performance. After controlling for neurocognitive variables, the group difference in second-order affective condition performance remained significant. These findings indicate that the affective component of ToM may be selectively impaired in OCD patients and that the observed deficit is largely independent of other neurocognitive impairments and clinical characteristics.
