Iron-Catalyzed Cleavage Reaction of Keto Acids with Aliphatic Aldehydes for the Synthesis of Ketones and Ketone Esters
作者：
Zhou, Fangyuan;Li, Lesong;Lin, Kao;Zhang, Feng;Deng, Guo-Jun;...
期刊：
CHEMISTRY-A EUROPEAN JOURNAL ,2020年26(19):4246-4250 ISSN：0947-6539
通讯作者：
Gong, Hang
作者机构：
[Zhou, Fangyuan; Li, Lesong; Deng, Guo-Jun; Lin, Kao; Gong, Hang] Xiangtan Univ, Coll Chem, Key Lab Green Organ Synth & Applicat Hunan Prov, Key Lab Environm Friendly Chem & Applicat,Minist, Xiangtan 411105, Peoples R China.;[Zhang, Feng] Hunan Agr Univ, Coll Sci, Changsha 410128, Peoples R China.
通讯机构：
[Gong, Hang] X;Xiangtan Univ, Coll Chem, Key Lab Green Organ Synth & Applicat Hunan Prov, Key Lab Environm Friendly Chem & Applicat,Minist, Xiangtan 411105, Peoples R China.
关键词：
catalysis;decarbonylation;decarboxylation;cross-coupling;synthetic methods
摘要：
The radical–radical coupling reaction is an important synthetic strategy. In this study, the iron-catalyzed radical–radical cross-coupling reaction based on the decarboxylation of keto acids and decarbonylation of aliphatic aldehydes to obtain valuable aryl ketones is reported for the first time. Remarkably, when tertiary aldehydes were used as carbonyl sources, ketone esters were selectively obtained instead of ketones. The gram-scale preparation of aryl ketone through this strategy was easily achieved by using only 3 mol % of the iron catalyst. As a proof-of-concept, the bioactive molecule flurprimidol was synthesized in two steps by using this strategy. © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
语种：
英文
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Bronsted acid-promoted thiazole synthesis under metal-free conditions using sulfur powder as the sulfur source
作者：
Ni, Penghui;Tan, Jing;Li, Rong;Huang, Huawen;Zhang, Feng* ;...
期刊：
RSC Advances ,2020年10(7):3931-3935 ISSN：2046-2069
通讯作者：
Deng, Guo-Jun;Zhang, Feng
作者机构：
[Li, Rong; Tan, Jing; Deng, Guo-Jun; Huang, Huawen; Ni, Penghui] Xiangtan Univ, Key Lab Green Organ Synth & Applicat Hunan Prov, Key Lab Environm Friendly Chem & Applicat, Minist Educ,Coll Chem, Xiangtan 411105, Peoples R China.;[Zhang, Feng] Hunan Agr Univ, Coll Sci, Changsha 410128, Peoples R China.
通讯机构：
[Deng, Guo-Jun] X;[Zhang, Feng] H;Xiangtan Univ, Key Lab Green Organ Synth & Applicat Hunan Prov, Key Lab Environm Friendly Chem & Applicat, Minist Educ,Coll Chem, Xiangtan 411105, Peoples R China.;Hunan Agr Univ, Coll Sci, Changsha 410128, Peoples R China.
摘要：
A Bronsted acid-promoted sulfuration/annulation reaction for the one-pot synthesis of bis-substituted thiazoles from benzylamines, acetophenones, and sulfur powder has been developed. One C-N bond and multi C-S bonds were selectively formed in one pot. The choice of the Bronsted acid was the key to the high efficiency of this transformation under metal-free conditions.
语种：
英文
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艺术土球:一种土壤学教育的新教具
作者：
盛浩;满志勇;李源钊;黄得志;张凤;...
期刊：
教育教学论坛 ,2020年(15):246-248 ISSN：1674-9324
作者机构：
湖南农业大学土壤研究所,湖南 长沙 410128;湖南农业大学理学院,湖南 长沙 410128;[张亮; 黄得志; 满志勇; 张凤; 盛浩; 李源钊] 湖南农业大学
关键词：
土壤美学功能;土壤颜色;土壤学课堂教学改革;土壤科普与教育;土壤艺术
摘要：
为增强学生对土壤美学的了解和提供相关的教学素材、教具,发挥土壤资源的美育功能,文章详细介绍了一种艺术土球教具的制作方法、步骤和注意事项;从美学构成因素上,分析了艺术土球的美学价值,包括简约的曲线美、立体的形象美和自然颜色的多样美。在学前、初等、高等和成人教育中,艺术土球不仅可用作教具演示,它的制作过程还有助于理解土壤科学原理,开发想象力、创造力和培养专注力、动手能力,提高艺术素养,缓解精神压力,是发展素质教育的一种手段。最后,展望艺术土球研发和在教育教学上的应用前景。
语种：
中文
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An ultrasensitive guanine wire-based resonance light scattering method using G-quadruplex self-assembly for determination of microRNA-122.
作者：
Zou, Rong;Zhang, Feng;Chen, Chunyan;Cai, Changqun*
期刊：
Microchimica Acta ,2019年186(9):599 ISSN：0026-3672
通讯作者：
Cai, Changqun
作者机构：
[Zou, Rong; Chen, Chunyan; Cai, Changqun] Xiangtan Univ, Coll Chem, Key Lab Green Organ Synth & Applicat Hunan Prov, Key Lab Environmentally Friendly Chem & Applicat, Xiangtan 411105, Peoples R China.;[Zhang, Feng] Hunan Agr Univ, Coll Sci, Changsha 410128, Hunan, Peoples R China.
通讯机构：
[Cai, Changqun] X;Xiangtan Univ, Coll Chem, Key Lab Green Organ Synth & Applicat Hunan Prov, Key Lab Environmentally Friendly Chem & Applicat, Xiangtan 411105, Peoples R China.
关键词：
guanine;guanine quadruplex;microRNA;MIRN122 microRNA, human;atomic force microscopy;cell line;chemistry;electrochemical analysis;genetic procedures;human;light;radiation scattering;spectrofluorometry;Biosensing Techniques;Cell Line;Electrochemical Techniques;G-Quadruplexes;Guanine;Humans;Light;MicroRNAs;Microscopy, Atomic Force;Scattering, Radiation;Spectrometry, Fluorescence
摘要：
An enzyme-free resonance light scattering (RLS) method is described for the determination of microRNA-122. A guanine nanowire (G-wire) is used that consists of a predesigned DNA1 and a G-quadruplex sequence DNA2. These hybridize with microRNA-122 and partially hybridize with DNA2. After formation of stable double strands with DNA1, DNA2 is released. On addition of K+ and Mg2+ ions, the G-quadruplex sequences undergo self-assembly to form long filamentous G-wires. This increases the intensity of RLS. A 6.1 pM detection limit was obtained, and the linear response covers the 50 pM to 300nM microRNA concentration range. The method was successfully applied to the quantitation of microRNA-122 in hepatocellular carcinoma cell lysates. Conceivably, this assay can be extended to other RLS methods for biomarker detection by simply changing the sequence of DNA1. [Figure not available: see fulltext.]. © 2019, Springer-Verlag GmbH Austria, part of Springer Nature.
语种：
英文
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Double G-quadruplexes in a copper nanoparticle based fluorescent probe for determination of HIV genes
作者：
Han, Yunpeng;Zhang, Feng;Gong, Hang* ;Cai, Changqun*
期刊：
Microchimica Acta ,2019年186(1):1-8 ISSN：0026-3672
通讯作者：
Gong, Hang;Cai, Changqun
作者机构：
[Cai, Changqun; Gong, Hang; Cai, CQ; Han, Yunpeng] Xiangtan Univ, Key Lab Green Organ Synth & Applicat Hunan Prov, Key Lab Environm Friendly Chem & Applicat, Minist Educ,Coll Chem, Xiangtan 411105, Peoples R China.;[Zhang, Feng] Hunan Agr Univ, Coll Sci, Changsha 410128, Hunan, Peoples R China.
通讯机构：
[Gong, H; Cai, CQ] X;Xiangtan Univ, Key Lab Green Organ Synth & Applicat Hunan Prov, Key Lab Environm Friendly Chem & Applicat, Minist Educ,Coll Chem, Xiangtan 411105, Peoples R China.
关键词：
copper;fluorescent dye;guanine quadruplex;metal nanoparticle;virus DNA;chemistry;genetic procedures;genetics;human;Human immunodeficiency virus;Biosensing Techniques;Copper;DNA, Viral;Fluorescent Dyes;G-Quadruplexes;HIV;Humans;Metal Nanoparticles
摘要：
A DNA-templated copper nanoparticle (CuNP) probe has been developed for the determination of the human immunodeficiency virus oligonucleotide (HIV-DNA). The function of the probe relies on affinity binding-induced DNA hybridization associated with the use of double G-quadruplexes. Double-stranded DNA(dsDNA) with poly(AT-TA) bases was used as a template for synthesis of dsDNA-CuNPs. These have weak fluorescence. In the next step, two G-rich sequences that are linked to both sides of the ds-DNA are locked by HIV complementary DNA (cDNA). If HIV-DNA is introduced, it will hybridize with cDNA, thereby transforming the two G-rich sequences into G-quadruplexes. This enhances the fluorescence of the adjacent dsDNA-CuNPs. Fluorescence increases linearly in the 1 to 200 and 250–1000nM HIV-DNA concentration range, and the detection limit is 13 pM. This enzyme-free fluorometric assay is time-saving, easily operated, and therefore has large potential in biosensing because it may be extended to various other DNA targets. [Figure not available: see fulltext.]. © 2018, Springer-Verlag GmbH Austria, part of Springer Nature.
语种：
英文
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Regioselectivity Control in the Oxidative Formal [3 + 2] Annulations of Ketoxime Acetates and Tetrohydroisoquinolines
作者：
Qu, Zhonghua;Zhang, Feng;Deng, Guo-Jun;Huang, Huawen*
期刊：
Organic Letters ,2019年21(20):8239-8243 ISSN：1523-7060
通讯作者：
Huang, Huawen
作者机构：
[Qu, Zhonghua; Deng, Guo-Jun; Huang, Huawen; Zhang, Feng] Xiangtan Univ, Coll Chem, Key Lab Green Organ Synth & Applicat Hunan Prov, Minist Educ,Key Lab Environm Friendly Chem & Appl, Xiangtan 411105, Peoples R China.;[Zhang, Feng] Hunan Agr Univ, Coll Sci, Changsha 410128, Hunan, Peoples R China.
通讯机构：
[Huang, Huawen] X;Xiangtan Univ, Coll Chem, Key Lab Green Organ Synth & Applicat Hunan Prov, Minist Educ,Key Lab Environm Friendly Chem & Appl, Xiangtan 411105, Peoples R China.
摘要：
A novel copper-catalyzed oxidative formal [3 + 2] annulations of ketoxime acetates and tetrohydroisoquinolines for the synthesis of fused pyrazoles and imidazoles has been developed. A broad range of important isoquinoline-fused pyrazole and imidazole products were selectively generated by the key control of oxidant.
语种：
英文
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Regio- and stereo-selective decarbonylative alkylative arylation of terminal alkynes with aliphatic aldehydes and arenes via dual C–H bond functionalization
作者：
Peng, Yong;Zhang, Feng;Qin, Ting-Ting;Xu, Cong-Ling;Yang, Luo*
期刊：
Organic Chemistry Frontiers ,2019年6(20):3597-3602 ISSN：2052-4110
通讯作者：
Yang, Luo
作者机构：
[Peng, Yong; Yang, Luo; Qin, Ting-Ting; Zhang, Feng; Xu, Cong-Ling] Xiangtan Univ, Key Lab Green Organ Synth & Applicat Hunan Prov, Key Lab Environmentally Friendly Chem & Applicat, Coll Chem,Minist Educ, Xiangtan 411105, Hunan, Peoples R China.;[Zhang, Feng] Hunan Agr Univ, Coll Sci, Changsha 410128, Hunan, Peoples R China.
通讯机构：
[Yang, Luo] X;Xiangtan Univ, Key Lab Green Organ Synth & Applicat Hunan Prov, Key Lab Environmentally Friendly Chem & Applicat, Coll Chem,Minist Educ, Xiangtan 411105, Hunan, Peoples R China.
关键词：
Aldehydes;Aromatic hydrocarbons;Chemical reactions;Aliphatic aldehydes;Alkyl radicals;Arylations;C-h bond functionalization;Radical addition;Stereo-selective;Terminal alkyne;Three component;Copper compounds
摘要：
A convenient Cu-promoted three-component decarbonylative alkylative arylation of terminal alkynes with aliphatic aldehydes and arenes is developed to provide chain elongated tri-substituted olefins with good chemo-, regio- and stereo-selectivities, and is applied to the radical-type decarbonylative coupling of sugar analogs. Readily available aliphatic aldehydes are readily decarbonylated into 1, 2 and 3 alkyl radicals for the construction of a C(sp3)-C(sp2) bond via radical addition, followed by HAS-arylation to form the C(sp2)-C(sp2) bond. © the Partner Organisations.
语种：
英文
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Nickel-Catalyzed Chemoselective Asymmetric Hydrogenation of α,β-Unsaturated Ketoimines: An Efficient Approach to Chiral Allylic Amines
作者：
Zhao, Xiang;Zhang, Feng;Liu, Kai;Zhang, Xumu;Lv, Hui*
期刊：
Organic Letters ,2019年21(22):8966-8969 ISSN：1523-7060
通讯作者：
Lv, Hui
作者机构：
[Zhao, Xiang; Liu, Kai; Lv, Hui] Wuhan Univ, Minist Educ, Key Lab Biomed Polymers, Wuhan 430072, Hubei, Peoples R China.;[Zhao, Xiang; Liu, Kai; Lv, Hui] Wuhan Univ, Coll Chem & Mol Sci, Engn Res Ctr Organosilicon Cpds & Mat, Minist Educ,Sauvage Ctr Mol Sci, Wuhan 430072, Hubei, Peoples R China.;[Zhang, Feng] Hunan Agr Univ, Coll Sci, Changsha 410128, Hunan, Peoples R China.;[Lv, Hui] Chinese Acad Sci, CAS Key Lab Mol Recognit & Funct, Inst Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China.;[Zhang, Xumu] Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Shenzhen 518055, Guangdong, Peoples R China.
通讯机构：
[Lv, Hui] W;[Lv, Hui] C;Wuhan Univ, Minist Educ, Key Lab Biomed Polymers, Wuhan 430072, Hubei, Peoples R China.;Wuhan Univ, Coll Chem & Mol Sci, Engn Res Ctr Organosilicon Cpds & Mat, Minist Educ,Sauvage Ctr Mol Sci, Wuhan 430072, Hubei, Peoples R China.;Chinese Acad Sci, CAS Key Lab Mol Recognit & Funct, Inst Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China.
摘要：
An efficient synthetic route to chiral allylic amines has been developed by nickel/(S,S)-Ph-BPE complex catalyzed chemoselective asymmetric hydrogenation of α,β-unsaturated ketoimines. Varieties of α,β-unsaturated ketoimines have been well tolerated in this transformation to give chiral allylic amines with high yields and excellent ee values (up to 99% yield, up to 99% ee). A gram-scale reaction with 0.2 mol % catalyst loading has also been achieved. © 2019 American Chemical Society.
语种：
英文
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Chemoselective metal-free indole arylation with cyclohexanones
作者：
Lu, Chaogang;Huang, Huawen* ;Tuo, Xiaolong;Jiang, Pingyu;Zhang, Feng;...
期刊：
Organic Chemistry Frontiers ,2019年6(15):2738-2743 ISSN：2052-4110
通讯作者：
Huang, Huawen;Deng, Guo-Jun
作者机构：
[Jiang, Pingyu; Deng, Guo-Jun; Huang, Huawen; Deng, GJ; Lu, Chaogang; Tuo, Xiaolong; Zhang, Feng] Xiangtan Univ, Coll Chem, Minist Educ, Key Lab Environm Friendly Chem & Applicat, Xiangtan 411105, Peoples R China.;[Zhang, Feng] Hunan Agr Univ, Coll Sci, Changsha 410128, Hunan, Peoples R China.
通讯机构：
[Huang, HW; Deng, GJ] X;Xiangtan Univ, Coll Chem, Minist Educ, Key Lab Environm Friendly Chem & Applicat, Xiangtan 411105, Peoples R China.
关键词：
Chemical reactions;Arylations;Chemoselective;Cyclohexanones;Elemental sulfur;Metal free;Polycyclic aromatic hydrocarbons
摘要：
Herein, we have revealed elemental sulfur-and iodine reagent-mediated indole C3 arylations using cyclohexanones as the arylating reagent. This protocol provides an efficient gram-scalable access to 3-Arylindole and benzo[4,5]thieno[2,3-b]indole motifs with a broad range of compatible functionalities. © the Partner Organisations.
语种：
英文
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Iron-Promoted Three-Component 2-Substituted Benzothiazole Formation via Nitroarene ortho-C–H Sulfuration with Elemental Sulfur
作者：
Xing, Qiaoyan;Ma, Yanfeng;Xie, Hao;Xiao, Fuhong;Zhang, Feng* ;...
期刊：
JOURNAL OF ORGANIC CHEMISTRY ,2019年84(3):1238-1246 ISSN：0022-3263
通讯作者：
Zhang, Feng;Deng, Guo-Jun
作者机构：
[Ma, Yanfeng; Xing, Qiaoyan; Zhang, Feng; Deng, GJ; Xie, Hao; Deng, Guo-Jun; Xiao, Fuhong] Xiangtan Univ, Coll Chem, Key Lab Green Organ Synth & Applicat Hunan Prov, Key Lab Environm Friendly Chem & Applicat,Minist, Xiangtan 411105, Peoples R China.;[Zhang, Feng] Hunan Agr Univ, Coll Sci, Changsha 410128, Hunan, Peoples R China.
通讯机构：
[Zhang, F; Deng, GJ] X;[Zhang, Feng] H;Xiangtan Univ, Coll Chem, Key Lab Green Organ Synth & Applicat Hunan Prov, Key Lab Environm Friendly Chem & Applicat,Minist, Xiangtan 411105, Peoples R China.;Hunan Agr Univ, Coll Sci, Changsha 410128, Hunan, Peoples R China.
关键词：
Chemical bonds;Sulfur;2-substituted benzothiazole;Benzothiazoles;C-s bond formations;Elemental sulfur;Nitroarenes;Sequential assembly;Sulfur powders;Three component;Iron;alcohol derivative;aromatic nitro compound;benzothiazole derivative;iron;nitrobenzene derivative;nitroreductase;sulfur;alcohol oxidation;Article;chemical bond;controlled study;reaction analysis;regioselectivity
摘要：
A three-component procedure for the preparation of 2-substituted benzothiazoles from nitroarenes, alcohols, and sulfur powder is described. The reaction showed a good functional group tolerance to provide the heterocyclic products in moderate to good yields. The sequential assembly involving nitro reduction, C-N condensation, and C-S bond formation has been realized in one pot. Copyright © 2019 American Chemical Society.
语种：
英文
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浅谈有机化学知识在高分子化学教学中的高效融合
作者：
张凤;盛浩
期刊：
山东化工 ,2019年48(18):193-194 ISSN：1008-021X
作者机构：
湖南农业大学理学院,湖南 长沙,410128;湖南农业大学资源与环境学院,湖南 长沙,410128;[张凤; 盛浩] 湖南农业大学
关键词：
有机化学;高分子化学;高分子合成;高分子改性
摘要：
有机化学是高分子化学课程之前重要的先修课程,为高分子材料合成提供了理论基础。在高分子化学教学过程中,结合有机化学知识,有利于帮助学生克服畏难心理,提高学生学习兴趣,加快学生对重点难点的理解,从而达到更好的教学效果。笔者结合十年高分子化学和有机化学的课堂教学经验,简要介绍在高分子化学课程教学中进行相关的有机化学知识有效融合的一些做法和心得体会。
语种：
中文
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研究生精细化学品课程教学改革初探
作者：
张凤;盛浩
期刊：
化工时刊 ,2019年33(10):61-62 ISSN：1002-154X
作者机构：
湖南农业大学理学院,湖南长沙,410128;湖南农业大学资源与环境学院,湖南长沙,410128;[张凤; 盛浩] 湖南农业大学
关键词：
精细化学品;教学改革;教学内容;案例教学;科研创新意识
摘要：
精细化学品与人们生活息息相关。为了培养精细化学品行业发展急需的应用型人才,笔者结合多年精细化学品化学课程教学经验,从理论课程的内容精选、更新及教学方法改进,到实验过程中全面提高学生的科研创新意识,均进行了积极探索,实现了理论教学与实践教学的紧密结合,让学生的专业知识及科研素养均得到了较大拓展与提高。
语种：
中文
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Three-Component Cascade Bis-heteroannulation of Aryl or Vinyl Methylketoxime Acetates toward Thieno[3,2-c]isoquinolines
作者：
Xu, Zhenhua;Deng, Guo-Jun* ;Zhang, Feng;Chen, Hongbiao;Huang, Huawen*
期刊：
Organic Letters ,2019年21(21):8630-8634 ISSN：1523-7060
通讯作者：
Deng, Guo-Jun;Huang, Huawen
作者机构：
[Chen, Hongbiao; Deng, GJ; Huang, Huawen; Deng, Guo-Jun; Xu, Zhenhua; Zhang, Feng] Xiangtan Univ, Minist Educ, Key Lab Environmentally Friendly Chem & Applicat, Coll Chem,Key Lab Green Organ Synth & Applicat Hu, Xiangtan 411105, Peoples R China.;[Zhang, Feng] Hunan Agr Univ, Coll Sci, Changsha 410128, Hunan, Peoples R China.
通讯机构：
[Deng, GJ; Huang, HW] X;Xiangtan Univ, Minist Educ, Key Lab Environmentally Friendly Chem & Applicat, Coll Chem,Key Lab Green Organ Synth & Applicat Hu, Xiangtan 411105, Peoples R China.
摘要：
A three-component cascade bis-heteroannulation reaction is described that provides access to a variety of benzo[4,5]thieno[3,2-c]isoquinoline and thieno[3,2-c]isoquinoline compounds from easily available methylketoximes, o-halobenzaldehydes, and elemental sulfur. Mechanistic studies reveal a two-step process involving a sequential copper and sulfur catalysis relay.
语种：
英文
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DNA-programming multicolor silver nanoclusters for sensitively simultaneous detection of two HIV DNAs
作者：
Zou, Rong;Zhang, Feng;Chen, Chunyan;Cai, Changqun*
期刊：
Sensors and Actuators B-Chemical ,2019年296:126608 ISSN：0925-4005
通讯作者：
Cai, Changqun
作者机构：
[Zou, Rong; Chen, Chunyan; Cai, Changqun] Xiangtan Univ, Key Lab Green Organ Synth & Applicat Hunan Prov, Key Lab Environm Friendly Chem & Applicat, Minist Educ,Coll Chem, Xiangtan 411105, Peoples R China.;[Zhang, Feng] Hunan Agr Univ, Coll Sci, Changsha 410128, Hunan, Peoples R China.
通讯机构：
[Cai, Changqun] X;Xiangtan Univ, Key Lab Green Organ Synth & Applicat Hunan Prov, Key Lab Environm Friendly Chem & Applicat, Minist Educ,Coll Chem, Xiangtan 411105, Peoples R China.
关键词：
Ag nanoclusters;Simultaneous detection;HIV DNA;Label-free
摘要：
A novel DNA-stabilized silver nanoclusters (AgNCs)-based label-free fluorescent platform for simultaneously detecting two human immunodeficiency virus oligonucleotides (HIV DNAs) was developed. The sensing platform was established based on fluorescence enhancement of guanine (G)-rich and the phenomenon in the process of two silver nanoclusters (AgNCs) forming a nanoclusters dimer. The probe (AgNCs/G) utilized for HIV-1 detection adopted an effective conformation based on enhancement effect of G-rich sequence (at 500 nm ex / 565 nm em) while the probe (AgNCs/AgNCs) for HIV-2 generated fluorescence signals (at 580 nm ex / 630 nm em) with bright fluorescence only in nanoclusters dimer. The nanoprobe shows high selectivity for multiplexed analysis of target DNA with a detection limit of 11 pM, respectively. Moreover, this is the first time to use the affectivity of fluorescent AgNCs and two HIV DNAs simultaneous detection integrated into a novel method, which shows a great promise in biomedical research and early clinical diagnosis.
语种：
英文
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MoS2-loaded G-quadruplex molecular beacon probes for versatile detection of MicroRNA through hybridization chain reaction signal amplification
作者：
Zhang, Feng;Wang, Shuang;Feng, Jian;Zou, Rong;Xiang, Ling;...
期刊：
Talanta ,2019年202:342-348 ISSN：0039-9140
通讯作者：
Cai, Changqun
作者机构：
[Feng, Jian; Zhang, Feng] Hunan Agr Univ, Coll Sci, Changsha 410128, Hunan, Peoples R China.;[Zou, Rong; Cai, Changqun; Xiang, Ling; Wang, Shuang] Xiangtan Univ, Key Lab Environmentally Friendly Chem & Applicat, Key Lab Green Organ Synth & Applicat Hunan Prov, Minist Educ,Coll Chem, Xiangtan 411105, Peoples R China.
通讯机构：
[Cai, Changqun] X;Xiangtan Univ, Key Lab Environmentally Friendly Chem & Applicat, Key Lab Green Organ Synth & Applicat Hunan Prov, Minist Educ,Coll Chem, Xiangtan 411105, Peoples R China.
关键词：
G-quadruplex;Hybridization chain reaction;Low-background;MoS(2) nanosheets
摘要：
A molecular beacons (MBs)loaded on molybdenum disulfide (MoS2)nanosheets as fluorescence probes for sensitive and versatile detection of microRNAs (miRNAs)through hybridization chain reaction (HCR)has been designed. MoS2 was used as a adsorbent to capture the MBs and a selective fluorescence quencher to reduce the background signal. In the absence of miRNAs, HCR could not be triggered due to the stability of MB probes. The probes attached to the MoS2 surface, efficiently quenching fluorescence of the G-quadruplex/Thioflavin T. However, the presence of target miRNAs triggers the HCR process to generate large amount of HCR products. Meanwhile, the HCR products of long nanowires chain with abundant G-quadruplexes could not be adsorbed on the surface of MoS2, and therefore detach from the MoS2. Consequently, Thioflavin T could be embedded in G-quadruplexes and produced strong fluorescence signal. This fluorescence emission signal could achieve detection of miRNA as low as 4.2 pM and a wide linear ranges from 0.1 to 100 nM. In addition, a versatile fluorescence probe has been developed for detection of miRNA-21 by changing the miRNA-recognition domain of MB. Thus, the fluorescent probe would be a potential alternative tool for biomedical research and clinical molecular diagnostics. © 2019 Elsevier B.V.
语种：
英文
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Metal- and solvent-free synthesis of amides using substitute formamides as an amino source under mild conditions.
作者：
Zhang, Feng* ;Li, Lesong;Zhang, Jingyu;Gong, Hang*
期刊：
Scientific Reports ,2019年9(1):2787 ISSN：2045-2322
通讯作者：
Zhang, Feng;Gong, Hang
作者机构：
[Zhang, Feng] Hunan Agr Univ, Coll Sci, Changsha 410128, Hunan, Peoples R China.;[Li, Lesong; Zhang, Jingyu; Gong, Hang] Xiangtan Univ, Coll Chem, Key Lab Environmentally Friendly Chem & Applicat, Key Lab Green Organ Synth & Applicat Hunan Prov, Xiangtan 411105, Peoples R China.
通讯机构：
[Zhang, Feng] H;[Gong, Hang] X;Hunan Agr Univ, Coll Sci, Changsha 410128, Hunan, Peoples R China.;Xiangtan Univ, Coll Chem, Key Lab Environmentally Friendly Chem & Applicat, Key Lab Green Organ Synth & Applicat Hunan Prov, Xiangtan 411105, Peoples R China.
摘要：
This study described an efficient and practical approach for amide synthesis. The reaction was conducted under metal- and solvent-free conditions at a mild temperature (40 degrees C) in air, and readily available formamides were used as an amino source. This reaction can be easily upgraded to the gram level with an excellent yield.
语种：
英文
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Four-component radical-dual-difunctionalization (RDD) and decarbonylative alkylative peroxidation of two different alkenes with aliphatic aldehydes and TBHP
作者：
Liu, Ren-Xiang;Zhang, Feng;Peng, Yong;Yang, Luo*
期刊：
Chemical Communications ,2019年55(80):12080-12083 ISSN：1359-7345
通讯作者：
Yang, Luo
作者机构：
[Peng, Yong; Yang, Luo; Liu, Ren-Xiang; Zhang, Feng] Xiangtan Univ, Coll Chem, Key Lab Green Organ Synth & Applicat Hunan Prov, Xiangtan 411105, Hunan, Peoples R China.;[Zhang, Feng] Hunan Agr Univ, Coll Sci, Changsha 410128, Hunan, Peoples R China.
通讯机构：
[Yang, Luo] X;Xiangtan Univ, Coll Chem, Key Lab Green Organ Synth & Applicat Hunan Prov, Xiangtan 411105, Hunan, Peoples R China.
摘要：
From difunctionalization of a single alkene to radical-dual-difunctionalization of two different alkenes! Abundant aliphatic aldehydes were readily decarbonylated into alkyl radicals for the cascade construction of C(sp3)-C(sp3), C(sp3)-C(sp3) and C(sp3)-O bonds via double radical addition and radical-radical coupling, following the intrinsic nucleophilic/electrophilic reactivity of both the radicals and alkenes. © The Royal Society of Chemistry.
语种：
英文
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Screening DNA-targeted anticancer drug in vitro based on cancer cells DNA-templated silver nanoclusters
作者：
Zhang, Feng;Sheng, Hao* ;Wang, Shuang;Ma, Yu;Cai, Changqun*
期刊：
Scientific Reports ,2019年9(1) ISSN：2045-2322
通讯作者：
Sheng, Hao;Cai, Changqun
作者机构：
[Ma, Yu; Zhang, Feng] Hunan Agr Univ, Coll Sci, Changsha 410128, Hunan, Peoples R China.;[Sheng, Hao] Hunan Agr Univ, Coll Resources & Environm, Changsha 410128, Hunan, Peoples R China.;[Cai, Changqun; Wang, Shuang] Xiangtan Univ, Coll Chem, Key Lab Environmentally Friendly Chem & Applicat, Key Lab Green Organ Synth & Applicat Hunan Prov, Xiangtan 411105, Peoples R China.
通讯机构：
[Sheng, Hao] H;[Cai, Changqun] X;Hunan Agr Univ, Coll Resources & Environm, Changsha 410128, Hunan, Peoples R China.;Xiangtan Univ, Coll Chem, Key Lab Environmentally Friendly Chem & Applicat, Key Lab Green Organ Synth & Applicat Hunan Prov, Xiangtan 411105, Peoples R China.
摘要：
<jats:title>Abstract</jats:title><jats:p>A reliable and sensitive cancer cells DNA-templated silver nanoclusters probe has been proposed for screening DNA-targeted anticancer drugs <jats:italic>in vitro</jats:italic>. In this paper, the DNA-templated silver nanoclusters was used to investigate the binding between anthracycline antibiotics and DNA. The template of DNA-templated silver nanoclusters was extracted from human liver carcinoma cells directly, which can express the drug activities against cancer cells more direct than the normal cells DNA. The anti-tumor activities of the four drugs were validated by MTT and apoptotic assay as Mitoxantrone > Epirubicin > Daunorubicin > Adriamycin.</jats:p>
语种：
英文
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浅谈工程教育认证背景下的高分子课程改革
作者：
张凤;王锦
期刊：
化工时刊 ,2019年33(04):54-55 ISSN：1002-154X
作者机构：
湖南农业大学理学院,湖南长沙,410128;[王锦; 张凤] 湖南农业大学
关键词：
工程认证;高分子;教学改革
摘要：
从本校材料化学专业工程教育认证的背景出发,从教学内容、教师队伍建设和考核方式等方面提出了高分子课程教学改革的新思路,并强调了在教学过程中,采用灵活多样的教学方法,注重理论联系实际,使该课程教学在工程教育认证中发挥支撑作用。
语种：
中文
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Multifunctional G-quadruplex-based fluorescence probe coupled with DNA-templated AgNCs for simultaneous detection of multiple DNAs and MicroRNAs
作者：
Han, Yunpeng;Zhang, Feng;Gong, Hang* ;Cai, Changqun*
期刊：
Analytica Chimica Acta ,2019年1053:105-113 ISSN：0003-2670
通讯作者：
Gong, Hang;Cai, Changqun
作者机构：
[Cai, Changqun; Gong, Hang; Cai, CQ; Han, Yunpeng] Xiangtan Univ, Key Lab Green Organ Synth & Applicat Hunan Prov, Key Lab Environm Friendly Chem & Applicat, Coll Chem,Minist Educ, Xiangtan 411105, Peoples R China.;[Zhang, Feng] Hunan Agr Univ, Coll Sci, Changsha 410128, Hunan, Peoples R China.
通讯机构：
[Gong, H; Cai, CQ] X;Xiangtan Univ, Key Lab Green Organ Synth & Applicat Hunan Prov, Key Lab Environm Friendly Chem & Applicat, Coll Chem,Minist Educ, Xiangtan 411105, Peoples R China.
关键词：
DNA-Templated AgNCs;Fluorescent;G-quadruplex-based;Multifunctional;Simultaneous detection
摘要：
A rapid, label-free, and multifunctional fluorescent probe for simultaneous detection of multiple targets was fabricated based on G-quadruplexes and DNA-templated silver nanoclusters (AgNCs). In this work, a probe with two capitated recognized regions was coupled with a locked G-quadruplex at the 5′-terminus and dark AgNC at the 3′-terminus. Upon the addition of the virus subtype H5N1 gene or microRNA-141, only the sequence of the G-quadruplex was released and bound with Thioflavin T (ThT) for a specific fluorescent response. On the contrary, with the presence of the influenza virus subtype H1N1 gene or microRNA-21, the fluorescence intensity was enhanced because of two split AgNCs approaching closely to produce a nanocluster dimer. Subsequently, with multiple target addition, fluorescence signals were produced for both G-quadruplexes and AgNCs. Moreover, this single and duplex detection for virus DNAs and microRNAs, which provides a versatile platform for different targets, was sufficiently sensitive for the expected detection limit, and still possessed unique selectivity with similar oligonucleotides. The simultaneous detection of targets in biological fluids indicated that there is great opportunity for this strategy to be further applied in biomedical research and clinical diagnosis. © 2018 Elsevier B.V.
语种：
英文
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