作者机构:
[Zhao, Jihui; Tang, Shengsong; Zeng, Luting; Zhao, Xuhong; Ning, Qian; Huang, Ruilei; Yi, Yi] Hunan Province Key Laboratory for Antibody-Based Drug and Intelligent Delivery System, School of Pharmaceutical Sciences, Hunan University of Medicine, Huaihua 418000, China;[Tang, Shengsong; Ning, Qian] College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha 410128, China;[Tang, Shengsong] Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, and Institute of Pharmacy & Pharmacology, University of South China, Hengyang 421001, China. Electronic address: tangshengsong@hunau.edu.cn
通讯机构:
[Tang, Shengsong] H;Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, and Institute of Pharmacy & Pharmacology, University of South China, Hengyang 421001, China. Electronic address:
摘要:
Cancer immunotherapy, particularly with immune checkpoint inhibitors, has revolutionized the paradigm of cancer treatment. Nevertheless, the efficacy of cancer immunotherapy remains limited in most clinical settings due to the lack of a preexisting antitumor T-cell response in tumors. Therefore, the clinical outcomes of cancer immunotherapy must be improved crucially. With increased awareness of the importance of the innate immune response in the recruitment of T cells, as well as the onset and maintenance of the T cell response, great interest has been shown in activating the cGAS-STING signaling pathway to awaken the innate immune response, thereby orchestrating both innate and adaptive immune responses to induce tumor clearance. However, tumor cells have evolved to overexpress ectonucleotide pyrophosphate phosphodiesterase 1 (ENPP1), which degrades the immunotransmitter 2',3'-cGAMP and promotes the production of immune-suppressing adenosine, resulting in inhibition of the anticancer immune response in the tumor microenvironment. Clinically, ENPP1 overexpression is closely associated with poor prognosis in patients with cancer. Conversely, depleting or inhibiting ENPP1 has been verified to elevate extracellular 2',3'-cGAMP levels and inhibit the generation of adenosine, thereby reinvigorating the anticancer immune response for tumor elimination. A variety of ENPP1 inhibitors have recently been developed and have demonstrated significant promise for cancer immunotherapy. In this review, we provide an overview of ENPP1, dissect its immunosuppressive mechanisms, and discuss the development of ENPP1 inhibitors with the potential to further improve the efficacy of cancer immunotherapy.
期刊:
Science of The Total Environment,2024年913:169601 ISSN:0048-9697
通讯作者:
Fu, Hui;Deng, Jianmin
作者机构:
[Fu, Hui] Ecology Department, College of Resources & Environments, Hunan Provincial Key Laboratory of Rural Ecosystem Health in Dongting Lake Area, Hunan Agricultural University, Changsha 410128, PR China. Electronic address: huifu367@163.com;[Li, Youzhi; Wu, Aiping; Ge, Yili; Liu, Huanyao; Cai, Guojun; Yuan, Guixiang] Ecology Department, College of Resources & Environments, Hunan Provincial Key Laboratory of Rural Ecosystem Health in Dongting Lake Area, Hunan Agricultural University, Changsha 410128, PR China;[Deng, Jianmin] Taihu Laboratory for Lake Ecosystem Research, State Key Laboratory of Lake Science and Environment, Nanjing Institute of Geography and Limnology, Chinese Academy of Sciences, Nanjing 210008, PR China. Electronic address: jmdeng@niglas.ac.cn;[Li, Wei] Research Institute of Ecology & Environmental Sciences, Nanchang Institute of Technology, Nanchang 330099, PR China;[Jeppesen, Erik] Department of Bioscience and Centre for Water Technology/WATEC, Aarhus University, Vejlsøvej 25, 8600 Silkeborg, Denmark
通讯机构:
[Deng, Jianmin] T;[Fu, Hui] E;Ecology Department, College of Resources & Environments, Hunan Provincial Key Laboratory of Rural Ecosystem Health in Dongting Lake Area, Hunan Agricultural University, Changsha 410128, PR China. Electronic address:;Taihu Laboratory for Lake Ecosystem Research, State Key Laboratory of Lake Science and Environment, Nanjing Institute of Geography and Limnology, Chinese Academy of Sciences, Nanjing 210008, PR China. Electronic address:
摘要:
Understanding how phytoplankton interacts with local and regional drivers as well as their feedbacks is a great challenge, and quantitative analyses of the regulating role of human activities and climate changes on these feedback loops are also limited. By using monthly monitoring dataset (2000-2017) from Lake Taihu and empirical dynamic modelling to construct causal networks, we quantified the strengths of causal feedbacks among phytoplankton, local environments, zooplankton, meteorology as well as global climate oscillation. Prevalent bidirectional causal linkages between phytoplankton biomass (chlorophyll a) and the tested drivers were found, providing holistic and quantitative evidence of the ubiquitous feedback loops. Phytoplankton biomass exhibited the highest feedbacks with total inorganic nitrogen and ammonia and the lowest with nitrate. The feedbacks between phytoplankton biomass and environmental factors from 2000 to 2017 could be classified into two groups: the local environments (e.g., nutrients, pH, transparency, zooplankton biomass)-driven enhancement loops promoting the response of the phytoplankton biomass, and the climate (e.g., wind speed)-driven regulatory loops suppressing it. The two counterbalanced groups modified the emergent macroecological patterns. Our findings revealed that the causal feedback networks loosened significantly after 2007 following nutrient loading reduction and unsuccessful biomanipulation restoration attempts by stocking carp. The strength of enhancement loops underwent marked decreases leading to reduced phytoplankton responses to the tested drivers, while the climate (decreasing wind speed, warming winter)-driven regulatory loops increased- like a tug-of-war. To counteract the self-amplifying feedback loops, the present eutrophication mitigation efforts, especially nutrient reduction, should be continued, and introduction of alternative measures to indirectly regulate the critical components (e.g., pH, Secchi depth, zooplankton biomass) of the loops would be beneficial.
摘要:
Soil salinity seriously hinders the sustainable development of green agriculture. The emergence of engineered nanomaterials has revolutionized agricultural research, providing a new means to overcome the limitations associated with current abiotic stress management and achieve highly productive agriculture. Herein, we synthesized a brand-new engineered nanomaterial (Cs-Se NMs) through the Schiff base reaction of oxidized chitosan with selenocystamine hydrochloride to alleviate salt stress in plants. After the addition of 300 mg/L Cs-Se NMs, the activity of superoxide dismutase, catalase, and peroxidase in rice shoots increased to 3.19, 1.79, and 1.85 times those observed in the NaCl group, respectively. Meanwhile, the MDA levels decreased by 63.9%. Notably, Cs-Se NMs also raised the transcription of genes correlated with the oxidative stress response and MAPK signaling in the transcriptomic analysis. In addition, Cs-Se NMs augmented the abundance and variety of rhizobacteria and remodeled the microbial community structure. These results provide insights into applying engineered nanomaterials in sustainable agriculture.
期刊:
Current Microbiology,2024年81(1):44 ISSN:0343-8651
作者机构:
[Dai, Yan-Na; Zhang, Yi-Fan; Pu, Ji-Feng] Institute of Agricultural Quality Standard and Testing, Tibet Academy of Agricultural and Animal Husbandry Sciences, Lhasa, 850032, China;[Dai, Yan-Na; Zhang, Yi-Fan; Pu, Ji-Feng] Agricultural and Livestock Products Engineering Technology Research Center of Tibet Autonomous Region, Lhasa, 850032, China;[Yang, Xiao-Feng] Institute of Agricultural Quality Standard and Testing Technology, Sichuan Academy of Agricultural Sciences, Chengdu, 610066, China;[Liu, Hu-Hu] College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, 410128, China;[Pan, Hu] Institute of Agricultural Quality Standard and Testing, Tibet Academy of Agricultural and Animal Husbandry Sciences, Lhasa, 850032, China. ph2032007@126.com
摘要:
A novel Gram-stain-negative, aerobic, rod-shaped bacterium named T808(T) was isolated from an alpine soil in Qamdo, Tibet, PR China. Strain T808(T) grew at 5-30℃, pH 5.0-9.0 (optimum, 25℃ and pH 7.0-8.0) with 0-2% (w/v) NaCl (optimum, 0%). The 16S rRNA gene sequences of strain T808(T) showed the highest similarity with Pararhizobium herbae CCBAU83011(T) (98.8%), followed by Pararhizobium polonicum F5.1(T) (98.7%), Pararhizobium giardinii H152(T) (98.5%), Rhizobium gei ZFJT-2(T) (98.4%), and Pararhizobium antarcticum NAQVI59(T) (97.5%). The highestdigital DNA-DNA hybridization (dDDH), core-proteome average amino acid identity (cpAAI) and average nucleotide identity (ANI) values between strain T808(T) and related strains were estimated as 28.0%, 92.1% and 84.4%, respectively. Phylogenetic analysis based on 16S rRNA, core-proteome and whole-genome indicated that strain T808(T) belonged to the genus Pararhizobium. The genome size was 6.24 Mbp with genomic DNA G + C content of 60.1%. The major cellular fatty acids were Summed feature 8 (C(18:1) ω7c or C(18:1) ω6c), C(16:0) and C(19:0) cyclo ω8c. The polar lipids were diphosphatidyl glycerol, phosphatidyl glycerol, phosphatidyl ethanolamine, phosphatidyl choline and unidentified aminophospholipid. The isoprenoid quinone were ubiquinone-10 and ubiquinone-9. Based on phenotypic, phylogenetic, and genotypic data, strain T808(T) is considered to represent a novel species of the genus Pararhizobium, for which the name Pararhizobium qamdonense sp. nov. is proposed. The type strain is T808(T) (= JCM 36247(T) = CICC 25216(T)). According to phylogenetic coherence based on 16S rRNA, core-proteome and whole-genome, it is also proposed that the type strain Rhizobium gei Shi et al. 2016 should be reclassified as Pararhizobium gei comb. nov., the type strain is ZFJT-2(T) (= CCTCC AB 2013015(T) = KCTC 32301(T) = LMG 27603(T)).
摘要:
The chemical structure of sinoacutine is formed by a phenanthrene nucleus and an ethylamine bridge. Because it has a similar parent structure to morphine, it is subdivided into morphinane. At present, all reports have pointed out that the basic skeleton of morphine alkaloids is salutaridine (the isomer of sinoacutine), which is generated by the phenol coupling reaction of (R)-reticuline. This study shows that the biosynthetic precursors of sinoacutine and salutaridine are different. In this paper, the sinoacutine synthetase (SinSyn) gene was cloned from Sinomenium acutum and expressed SinSyn protein. Sinoacutine was produced by SinSyn catalyzed (S)-reticuline, according to the results of enzyme-catalyzed experiments. The optical activity, nuclear magnetic resonance, and mass spectrum of sinoacutine and salutaridine were analyzed. The classification and pharmacological action of isoquinoline alkaloids were discussed. It was suggested that sinoacutine should be separated from morphinane and classified as sinomenine alkaloids.
期刊:
Frontiers in Immunology,2024年14:1285442 ISSN:1664-3224
作者机构:
[Hu, Siwang; Li, Siying; Chang, Jiang] The Orthopaedic Center, The First People's Hospital of Wenling, Wenling Hospital of Wenzhou Medical University, Wenling, Zhejiang, China;[Liu, Gang; Han, Xuebing; Liu, Naiyuan; Li, Siying] College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, Hunan, China
关键词:
L. plantarum;dexamethasone;differential metabolites;food active ingredients;glucocorticoids;gut microbes;osteoporosis;probiotics
摘要:
INTRODUCTION: Osteoporosis, one of the most common non-communicable human diseases worldwide, is one of the most prevalent disease of the adult skeleton. Glucocorticoid-induced osteoporosis(GIOP) is the foremost form of secondary osteoporosis, extensively researched due to its prevalence.Probiotics constitute a primary bioactive component within numerous foods, offering promise as a potential biological intervention for preventing and treating osteoporosis. This study aimed to evaluate the beneficial effects of the probiotic Lactobacillus plantarum on bone health and its underlying mechanisms in a rat model of glucocorticoid dexamethasone-induced osteoporosis, using the osteoporosis treatment drug alendronate as a reference. METHODS: We examined the bone microstructure (Micro-CT and HE staining) and analyzed the gut microbiome and serum metabolome in rats. RESULTS AND DISCUSSION: The results revealed that L. plantarum treatment significantly restored parameters of bone microstructure, with elevated bone density, increased number and thickness of trabeculae, and decreased Tb.Sp. Gut microbiota sequencing results showed that probiotic treatment increased gut microbial diversity and the ratio of Firmicutes to Bacteroidota decreased. Beneficial bacteria abundance was significantly increased (Lachnospiraceae_NK4A136_group, Ruminococcus, UCG_005, Romboutsia, and Christensenellaceae_R_7_group), and harmful bacteria abundance was significantly decreased (Desulfovibrionaceae). According to the results of serum metabolomics, significant changes in serum metabolites occurred in different groups. These differential metabolites were predominantly enriched within the pathways of Pentose and Glucuronate Interconversions, as well as Propanoate Metabolism. Furthermore, treatment of L. plantarum significantly increased serum levels of Pyrazine and gamma-Glutamylcysteine, which were associated with inhibition of osteoclast formation and promoting osteoblast formation. Lactobacillus plantarum can protect rats from DEX-induced GIOP by mediating the "gut microbial-bone axis" promoting the production of beneficial bacteria and metabolites. Therefore L. plantarum is a potential candidate for the treatment of GIOP.
作者机构:
[Tian, Yun; Zhao, Qiaoqin; Chen, Hong; Lu, Xiangyang; Liu, Ziying; Huang, Mingkang; Hu, Pengcheng] College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, Hunan 410128, China;[Tian, Yun] State Key Laboratory of Utilization of Woody Oil Resource, Hunan Academy of Forestry, Changsha, Hunan 410004, China;[Li, Changzhu; Li, Peiwang] State Key Laboratory of Utilization of Woody Oil Resource, Hunan Academy of Forestry, Changsha, Hunan 410004, China;[Ji, Xiaojun] College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, Jiangsu 211816, China;[Liu, Huhu] College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, Hunan 410128, China. Electronic address: liuhuhu@hunau.edu.cn
通讯机构:
[Liu, Huhu] C;College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, Hunan 410128, China. Electronic address:
摘要:
Squalene is an important triterpene with a wide range of applications. Given the growing market demand for squalene, the development of microbial cell factories capable of squalene production is considered a sustainable method. This study aimed to investigate the squalene production potential of Yarrowia lipolytica. First, HMG-CoA reductase from Saccharomyces cerevisiae and squalene synthase from Y. lipolytica was co-overexpressed in Y. lipolytica. Second, by enhancing the supply of NADPH in the squalene synthesis pathway, the production of squalene in Y. lipolytica was effectively increased. Furthermore, by constructing an isoprenol utilization pathway and overexpressing YlDGA1, the strain YLSQ9, capable of producing 868.1 mg/L squalene, was obtained. Finally, by optimizing the fermentation conditions, the highest squalene concentration of 1628.2 mg/L (81.0 mg/g DCW) in Y. lipolytica to date was achieved. This study demonstrated the potential for achieving high squalene production using Y. lipolytica.
期刊:
Journal of Nutritional Biochemistry,2024年:109505 ISSN:0955-2863
通讯作者:
Liu, Gang;Fang, Jun
作者机构:
[Liu, Yihui] College of Bioscience and Biotechnology, Hunan Agricultural University, Hunan Provincial Engineering Research Center of Applied Microbial Resources Development for Livestock and Poultry, Changsha, Hunan 410128, China;[Liu, Gang] College of Bioscience and Biotechnology, Hunan Agricultural University, Hunan Provincial Engineering Research Center of Applied Microbial Resources Development for Livestock and Poultry, Changsha, Hunan 410128, China.. Electronic address: gangle.liu@gmail.com;[Fang, Jun] College of Bioscience and Biotechnology, Hunan Agricultural University, Hunan Provincial Engineering Research Center of Applied Microbial Resources Development for Livestock and Poultry, Changsha, Hunan 410128, China.. Electronic address: fangjun1973@hunau.edu.cn
通讯机构:
[Liu, Gang; Fang, Jun] C;College of Bioscience and Biotechnology, Hunan Agricultural University, Hunan Provincial Engineering Research Center of Applied Microbial Resources Development for Livestock and Poultry, Changsha, Hunan 410128, China.. Electronic address: gangle.;College of Bioscience and Biotechnology, Hunan Agricultural University, Hunan Provincial Engineering Research Center of Applied Microbial Resources Development for Livestock and Poultry, Changsha, Hunan 410128, China.. Electronic address:
摘要:
Ulcerative colitis (UC) is a chronic, non-specific inflammatory sickness of the intestinal tract, chiefly implicating the rectum and colon, which is characterized by chronic or subacute diarrhea, mucopurulent stools, and abdominal pain. The pathogeny of UC is still uncertain, and it is thought that multiple factors interact to cause the disease, such as environment, genetics, gut microbes, and immunity. Injure to the intestinal barrier is one of the most significant features of UC and includes mechanical, chemical, immune, and biological barriers. Plenty of research has shown that probiotics, as profitable bacteria in the gut, can play a prominent role in the treatment of UC by improving gut barrier function and modulating gut immunity. Lactobacillus plantarum (L. plantarum), a common probiotic, has made outstanding contributions to food and medicine, and many studies in recent years have shown that Lactobacillus plantarum has great preventive and therapeutic effects on ulcerative colitis and restores the intestinal barrier. This paper reviews the mechanisms of L. plantarum for improving the intestinal barrier function of UC organisms, mainly including regulating the immune response, inhibiting oxidative stress, raising the expression of tight junction (TJ) proteins, promoting the formation of mucin, improving the composition of gut flora, and raising the levels of short-chain fatty acids (SCFAs), which offers some help for the clinical therapy of UC.
期刊:
Journal of Nutritional Biochemistry,2024年:109488 ISSN:0955-2863
通讯作者:
Fang, Jun
作者机构:
[Liu, Gang; Yao, Bin; Su, Zhan] College of Bioscience and Biotechnology, Hunan Agricultural University, Hunan Provincial Engineering Research Center of Applied Microbial Resources Development for Livestock and Poultry, Changsha, Hunan 410,128 China;[Fang, Jun] College of Bioscience and Biotechnology, Hunan Agricultural University, Hunan Provincial Engineering Research Center of Applied Microbial Resources Development for Livestock and Poultry, Changsha, Hunan 410,128 China. Electronic address: fangjun1973@hunau.edu.cn
通讯机构:
[Fang, Jun] C;College of Bioscience and Biotechnology, Hunan Agricultural University, Hunan Provincial Engineering Research Center of Applied Microbial Resources Development for Livestock and Poultry, Changsha, Hunan 410,128 China. Electronic address:
摘要:
Osteoporosis (OP) is a skeletal disorder characterized by decreased bone density, alterations in bone microstructure, and increased damage to the bones. As the population ages and life expectancy increases, OP has become a global epidemic, drawing attention from scientists and doctors. Because of polyphenols have favorable antioxidant and anti-allergy effects, which are regarded as potential methods to prevent angiocardipathy and OP. Polyphenols offer a promising approach to preventing and treating OP by affecting bone metabolism, reducing bone resolution, maintaining bone density, and lowering the differentiation level of osteoclasts(OC). There are multiple ways in which polyphenols affect bone metabolism. This article provides an overview of how polyphenols inhibit oxidative stress, exert antibacterial effects, and prevent the occurrence of OP. Furthermore, we will explore the regulatory mechanisms and signaling pathways implicated in this process. Mini Abstract: Osteoporosis(OP) is a systemic bone disease characterized by a decrease in bone density and quality, resulting in increased bone fragility and a higher risk of fractures. Polyphenols are natural compounds recognized for their antioxidant activity and anti-inflammatory effects. This review aims to explore the molecular mechanisms that underlie the impact of polyphenols on OP.
期刊:
Science of The Total Environment,2024年908:168430 ISSN:0048-9697
通讯作者:
Fang, Jun;Xiao, Yunhua
作者机构:
[Zhang, Xuerong; Chen, Liang; Wang, Ying; Li, Zhihuan; Duan, Shuyang] College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha 410128, China;[Fang, Jun] College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha 410128, China. Electronic address: fangjun1973@hunau.edu.cn;[Xiao, Yunhua] College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha 410128, China. Electronic address: xyh2017@hunau.edu.cn
通讯机构:
[Fang, Jun; Xiao, Yunhua] C;College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha 410128, China. Electronic address:
关键词:
Cd fractionation;Microbial community;Migration and transformation
摘要:
The issue of heavy metal pollution caused by human production and living activities is progressively worsening. This study explored the effect of iron-rich organic fertilizer on the growth, quality, and cadmium (Cd) absorption of Chinese cabbage under Cd stress. The results showed that iron-rich organic fertilizer could increase the soluble protein content and root length of Chinese cabbage. Meanwhile, it could change the form of Cd to inhibit the enrichment of Cd in Chinese cabbage. The alkali hydrolyzed nitrogen (AN), total potassium (TK), organic matter (OM), and moisture content (MC) of the Z3 treatment group (2% ferrous sulfate heptahydrate) were significantly higher than those of other treatment groups. The microbial network of Z3 was more complex than the other three groups. PICRUSt analysis and correlation analysis showed that the genes related to protein synthesis (e.g., glutathione S-transferase, zinc and Cd transporter, outer membrane protein, ArsR family transcriptional regulator, catalase, etc.) can also promote microbial absorption. This study aims to provide theoretical insights into soil Cd pollution immobilization techniques.
通讯机构:
[Tiean Zhou; Yanyang Wu] C;College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha 410128, China<&wdkj&>Hunan Provincial Engineering Technology Research Center for Cell Mechanics and Function Analysis, Changsha 410128, China<&wdkj&>College of Food Science and Technology, Hunan Agricultural University, Changsha 410128, China
摘要:
HYPOTHESIS: Construction of dual gatekeepers-functionalized mesoporous organic silica nanoparticles (MONs) with both physical and chemical mechanisms for modulated drug delivery properties provides one solution to the extracellular stability vs. intracellular high therapeutic efficiency of MONs that hold great potential for clinical translations. EXPERIMENTS: We reported herein facile construction of diselenium-bridged MONs decorated with dual gatekeepers, i.e., azobenzene (Azo)/polydopamine (PDA) for both physical and chemical modulated drug delivery properties. Specifically, Azo can act as a physical barrier to block DOX in the mesoporous structure of MONs for extracellular safe encapsulation. The PDA outer corona serves not only as a chemical barrier with acidic pH-modulated permeability for double insurance of minimized DOX leakage in the extracellular blood circulation but also for inducing a PTT effect for synergistic PTT and chemotherapy of breast cancer. FINDINGS: An optimized formulation, DOX@(MONs-Azo3)@PDA resulted in approximately 1.5 and 2.4 fold lower IC50 values than DOX@(MONs-Azo3) and (MONs-Azo3)@PDA controls in MCF-7 cells, respectively, and further mediated complete tumor eradication in 4T1 tumor-bearing BALB/c mice with insignificant systematic toxicity due to the synergistic PTT and chemotherapy with enhanced therapeutic efficiency.
作者:
Robert, Hélène S.;Heisler, Marcus G.;Xiao, Langtao;Landrein, Benoit
期刊:
Frontiers in Plant Science,2023年14:1319859 ISSN:1664-462X
作者机构:
Hormonal Crosstalk in Plant Development, Mendel Center for Plant Genomics and Proteomics, Central European Institute of Technology, Masaryk University (CEITEC MU), Czechia;School of Life and Environmental Sciences, University of Sydney, Australia;College of Bioscience and Biotechnology, Hunan Agricultural University, China;Laboratoire Reproduction et Développement des Plantes, Université de Lyon, ENS de Lyon, UCB Lyon, CNRS, INRAE, INRIA, France
摘要:
IntroductionPhytohormones shape the plant above and below ground to enable grounding, interaction with the soil microbiome and with surrounding plants, water and nutrient uptake, organ production, photosynthesis optimization, and seed production. The plant aerial architecture results from the dynamic processes of shoot branching, leaf and flower production following phyllotaxis, and reproduction that originate from the post-embryonic activity of the shoot apical meristem. Hormones influence and coordinate plant development and physiology at the organism level. Different hormones regulate different aspects of shoot development, acting together or antagonistically. This Research Topic compiles seven articles, e.g., four original research and three review articles, dealing with the influence of hormones on shoot development, branching regulation, flower aging, and fruit maturation. They show that all these processes are influenced by many different hormones, such as ethylene, gibberellins, abscisic acid, auxin, cytokinin, and strigolactones.Shooting and Branching processes - A hub for hormonal crosstalkPost-embryonic shoot organogenesis depends on the activity of the shoot apical meristem (SAM). The SAM contains a pool of slow-growing stem cells in the central zone (CZ), surrounded by fast-growing cells in the peripherical zone (PZ), where organs are initiated. It is structured in three cell layers. The SAM is maintained through the WUSCHEL (WUS) – CLAVATA 3 (CLV3) module (Gr...
通讯机构:
[Zeng, CZ ] C;[Yan, ML ; Tong, JH ] H;Cent South Univ Forestry & Technol, Hunan Prov Key Lab Forestry Biotechnol, Coll Life Sci & Technol, Changsha 410004, Peoples R China.;Hunan Agr Univ, Coll Biosci & Biotechnol, Hunan Prov Key Lab Phytohormones & Growth Dev, Changsha 410128, Peoples R China.;Hunan Acad Agr Sci, Crop Res Inst, Changsha 410125, Peoples R China.
摘要:
Metabolic profiles in xylem sap are considered a fundamental mechanism for Cd detoxification in plants. However, the metabolic mechanism of Brassica juncea xylem sap in response to Cd is still unclear. Here, we investigated the effects on the metabolomics of B. juncea xylem sap treated with Cd at different times by utilizing a non-targeted LC-MS-based metabolomics method for further elucidating the response mechanism of Cd exposure. The findings indicated that 48 h and 7 d Cd exposure caused significant differences in metabolic profiles of the B. juncea xylem sap. Those differential metabolites are primarily involved in amino acids, organic acids, lipids, and carbohydrates, and most of them were downregulated, which played essential roles in response to Cd stress. Furthermore, B. juncea xylem sap resisted 48 h Cd exposure via regulation of glycerophospholipid metabolism, carbon metabolism, aminoacyl-tRNA biosynthesis, glyoxylate and dicarboxylate metabolism, linoleic acid metabolism, C5-branched dibasic acid metabolism, alpha-linolenic acid metabolism, cyanoamino acid metabolism, ABC transporters, biosynthesis of amino acids, and pyrimidine metabolism; whereas alpha-linolenic acid metabolism, glycerophospholipid metabolism, photosynthesis, and oxidative phosphorylation were regulated for resisting 7 d Cd exposure. This article is protected by copyright. All rights reserved.
摘要:
The components of a protein complex involved in recognizing the histone modification H3K27me3 and transcriptional repression function in an epigenetic module that negatively regulates the N‐hydroxypipecolic acid biosynthesis gene FLAVIN‐DEPENDENT MONOOXYGENASE 1. ABSTRACT N‐Hydroxypipecolic acid (NHP) is a signaling molecule crucial for systemic acquired resistance (SAR), a systemic immune response in plants that provides long‐lasting and broad‐spectrum protection against secondary pathogen infections. To identify negative regulators of NHP biosynthesis, we performed a forward genetic screen to search for mutants with elevated expression of the NHP biosynthesis gene FLAVIN‐DEPENDENT MONOOXYGENASE 1 (FMO1). Analysis of two constitutive expression of FMO1 (cef) and one induced expression of FMO1 (ief) mutants revealed that the AIPP3–PHD2–CPL2 protein complex, which is involved in the recognition of the histone modification H3K27me3 and transcriptional repression, contributes to the negative regulation of FMO1 expression and NHP biosynthesis. Our study suggests that epigenetic regulation plays a crucial role in controlling FMO1 expression and NHP levels in plants.
期刊:
Frontiers in Plant Science,2023年14:1239758 ISSN:1664-462X
通讯作者:
Müller, M.
作者机构:
[Müller, Maren] Department of Evolutionary Biology, Ecology and Environmental Sciences, Faculty of Biology, University of Barcelona, Barcelona, Spain;[Wang, Ruozhong] Hunan Provincial Key Laboratory of Phytohormones and Growth Development, Hunan Agricultural University, Changsha, China;[Kudoyarova, Guzel] Ufa Institute of Biology, Ufa Federal Research Centre, Russian Academy of Sciences, Ufa, Russian Federation
通讯机构:
[Müller, M.] D;Department of Evolutionary Biology, Spain
关键词:
plant hormones;Climate Change;bio c stress;abio c stress;hormone signaling;14 hormone interac on;plant adapta on;plant stress tolerance 15
摘要:
warming, the evolu on of pathogenic threats and extreme weather condi ons have a great 21 impact on the plant ecosystem. Intense and unpredictable climate events are likely to exacerbate 22 the food crisis, par cularly in terms of ensuring global food security. Thus, climate-resilient 23 agriculture is crucial to securing future harvests, and scien sts around the world are involved in 24 developing solu ons. In this context, plant hormones, also known as phytohormones, play a 25 pivotal role, as they not only regulate plant growth and development, but also regulate the 26 plant's ability to react to environmental changes. Plant hormones include a wide variety of 27 compounds, including auxins, cytokinins, gibberellins, abscisic acid, salicylic acid, ethylene, 28 jasmonates, brassinosteroids, strigolactones and some pep des. Although it is now well known 29 that plant hormones act through complex networks, many gaps remain regarding their 30 interac ons and feedback loops that connect their signaling pathways. This research topic aims 31 to collect original research, perspec ve, as well as hypothesis and theory papers on our 32 knowledge of recent advances in plant hormone research under changing environmental stress 33 condi ons. 34The perspec ve ar cle by Wang et al. presents a novel view on the plant transcrip on factor Dof 36 (DNA-binding with one finger) as a key regulatory hub of abscisic acid, jasmonates, salicylates, 37 and redox signaling in responses to abio c str...